胃纳欣颗粒的质量标准研究  

Study on quality standard of Weinaxin granular

作　　者：赵昕[1] 王沈歌[2] 许志军[3] 陈明明[1] 

机构地区：[1]沈阳军区联勤部药品仪器检验所,辽宁沈阳110026 [2]沈阳军区总医院,辽宁沈阳110016 [3]吉林大学公共计算机教学与研究中心,吉林长春130062

出　　处：《药学实践杂志》2016年第2期167-170,共4页Journal of Pharmaceutical Practice

摘　　要：目的制定胃纳欣颗粒质量控制标准。方法采用薄层色谱（TLC）法对胃纳欣颗粒中半夏、茯苓、甘草、枳壳、白芷进行定性鉴别;采用反相高效液相色谱（HPLC）法对柚皮苷进行定量测定。结果半夏、茯苓、甘草、枳壳、白芷可用TLC法进行定性鉴别;HPLC法测定柚皮苷可达基线分离,紫外检测器在0.084 4~0.295 4μg时线性良好,回归方程：Y=2×106 X＋14 691,r=0.999 3,6次测定平均加样回收率为98.74%,RSD为1.20%。结论该法可准确定性、定量,能有效控制该制剂的质量。Objective To establish a quality standard of Weinaxin granular.Methods Pinelliae Rhizoma,Poria,Glycyrrhizae,Radix Angelicae,Aurantii Fructus were identified by TLC,and the assay of Narigin in Aurantii Fructus was performed by reverse phase HPLC.Results Pinelliae Rhizoma,Poria,Glycyrrhizae,Radix Angelicae,Aurantii Fructus can be identified by TLC.The HPLC method for Narigin shows a baseline separation with a linear calibration curve in the range of 0.084 4~0.295 4μg（r=0.999 3）.The average recovery of the method was 98.74%.The RSD was 1.20%（n=6）.Conclusion This method was reliable and accurate,can be used for the quality control of this product.

关 键 词：胃纳欣颗粒 薄层色谱法 高效液相色谱法 柚皮苷 

分 类 号：R93[医药卫生—生药学]