加压氧联合醒脑静注射液治疗颅脑创伤后脑梗死效果  

EFFECTS OF HYPERBARIC OXYGEN COMBINED WITH XINGNAOJING INJECTION ON CEREBRAL INFARCTION AFTER CRANIOCEREBRAL TRAUMA

作　　者：裴荣权 孟令文[1] 张永明[1] 

机构地区：[1]中国人民解放军第102医院神经外科,江苏常州213003

出　　处：《齐鲁医学杂志》2016年第1期72-73,76,共3页Medical Journal of Qilu

摘　　要：目的探讨颅脑创伤后脑梗死行加压氧联合醒脑静注射液治疗的临床效果。方法选择本院收治的颅脑创伤后脑梗死病人122例,随机分为对照组和治疗组,每组61例。对照组给予常规治疗和加压氧治疗;治疗组在对照组基础上应用醒脑静注射液治疗。10d为1个疗程,连续治疗2个疗程。评估两组治疗效果,观察病人意识恢复时间;进行神经功能缺损程度（AS）评分、肢体功能FM评分和巴氏指数（BI）评分;测定病人血清血液黏度、红细胞聚集指数和纤维蛋白原水平。结果治疗组病人总有效率为88.52%（54/61）,高于对照组的67.21%（41/61）,差异有统计学意义（χ~2=8.038,P〈0.05）。治疗组病人意识恢复时间短于对照组,差异有统计学意义（t=8.003,P〈0.05）。治疗后治疗组AS评分低于对照组,FM和BI评分高于对照组,差异均具有统计学意义（t=4.23~23.37,P〈0.05）。治疗后治疗组病人全血黏度、红细胞聚集指数和纤维蛋白原水平均低于对照组,差异有统计学意义（t=5.87~16.69,P〈0.05）。结论加压氧联合醒脑静注射液治疗颅脑创伤后脑梗死的效果显著,能够缩短病人意识恢复时间,改善血流状况,促进病人脑功能恢复。Objective To assess clinical efficacy of hyperbaric oxygen combined with Xingnaojing injection in the treatment for cerebral infarction after craniocerebral trauma（CCT）. Methods This study enrolled 122 patients treated in our hospital for infarction of the brain after CCT,who were divided into control group and treatment group in random,with 61 patients in each group.Patients in the control group received conventional treatment and hyperbaric oxygen,and those in the treatment group were given Xingnaojing injection in addition to that used in the control group.The treatment lasted for 20days（two courses）.The treatment effectiveness in the two groups was evaluated,and the time of return of consciousness was observed.Score of neurologic impairment（AS score）,of limb function（FM score）and of Barthel Index（BI）were performed.Blood viscosity,erythrocyte aggregation index and fibrinogen index were detected. Results The total effective rate in the treatment group was 88.52%（54/61）,being higher than the control group of 67.21%（41/61）（χ~2=8.038,P〈0.05）.The time of return of consciousness was shorter in the treatment group than that in the control（t=8.003,P〈0.05）.After treatment,AS score of patients in the treatment group was significantly lower than the control group,FM and BI scores were higher,the differences being statistically significant（t=4.23-23.37,P〈0.05）.The whole blood viscosity,erythrocyte aggregation index and fibrinogen in the treatment group were lower than that in the control group（t=5.87-16.69,P〈0.05）. Conclusion The effectiveness of hyperbaric oxygen combined with Xingnaojing injection is notable for cerebral infarction after craniocerebral trauma,this therapy can shorten the consciousness recovery time,improve blood flow and promote functional rehabilitation of patients.

关 键 词：颅脑损伤 脑梗死 高压氧 醒脑静注射液 治疗结果 

分 类 号：R651.15[医药卫生—外科学]