应用斯锑黑克治疗荒漠型黑热病的疗效检测  

Evaluation on the therapeutic effect of Stibogluconate on the desert-type Kala-azar

作　　者：付玉华[1] 杜春辉[2] 徐恩洁[3] 徐艺玫 徐兵[5] 廖力夫 

机构地区：[1]新疆自治区人民医院北院,新疆乌鲁木齐830000 [2]新疆喀什地区第一人民医院,新疆喀什844000 [3]新疆医科大学第一附属医院,新疆乌鲁木齐830011 [4]新疆实验动物研究中心,新疆乌鲁木齐830002 [5]新疆疾病预防控制中心,新疆乌鲁木齐830002

出　　处：《中国卫生检验杂志》2016年第6期761-764,共4页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金(30460120;30760217)

摘　　要：目的观查斯锑黑克治疗荒漠型黑热病的临床效果。方法 r K39金标法和ELISA夹心法检测黑热病抗体,B超仪测量脾脏的长度和厚度,全自动分析仪进行血液及生化检测。结果荒漠型黑热病患者42例,黑热病抗体全部阳性;治疗前脾脏的长度和厚度分别为正常的1.67倍和1.81倍,治疗后基本恢复正常;白细胞、红细胞、血红素、血小板治疗后显著升高（t值为3.633-6.422,P〈0.01）,草转氨酶降低（t值为2.455,P〈0.05）,恢复正常,前后差异具有统计学意义（P〈0.05）。治疗前后血清球蛋白、谷丙转氨酶均处于正常范围。结论荒漠型黑热病的主要症状为脾脏肿大,严重贫血,营养不良,肝功能损伤;本次用斯锑黑克治疗荒漠型黑热病的总剂量为（278.4±39.2）mg/kg,分6次-10次给药,（16±6）d全部出院,至今6年没有发现复发或再感染。Objective To evaluate the therapeutic effect of sodium Stibogluconate on the desert- type Kala- azar. Methods Gold- labelled r K39 detection method and sandwich ELISA were used to detect the antibody of Kala- azar. The length and thickness of spleen were assayed using supersonic reflectoscope. The blood and biochemical values were measured by automatic biochemical analyzer. Results It was showed that the antibodies of 42 collected patients with Kala- azar were all positive. The length and thickness of spleen pre- treated were 1. 67 and 1. 81 times to the normal,respectively,and the spleen recovered after treatment. After treatment,WBC,RBC,HGB,PLT raised（ t = 3. 633- 6. 422,P〈0. 01）,AST reduced（ t =2. 455,P〈0. 05）,and return to normal,in which the difference was statistically significant in pre- treatment and post- treatment. The serum ALT and GLB were among normal range in pre- treatment and post- treatment. Conclusion The main symptoms of desert- type Kala- azar are splenomegaly,severe anemia,malnutrition and liver damage; the dosage of stibogluconate for the treatment of desert- type Kala- azar is（ 278. 4 ± 39. 2） mg / kg,and patients can recovered after（ 16 ± 6） days of treatment with 6- 10 doses. So far,we have not found any relapse or reinfection cases in the last 6 years.

关 键 词：荒漠型黑热病 实验室检验 斯锑黑克 治疗 

分 类 号：R531.6[医药卫生—内科学]