Assessment of silver(Ⅰ) complexes of salicylaldehyde derivatives—histidine Schiff base as novel a-glucosidase inhibitors  

作　　者：Jing-Wei Zheng Lin Ma 

机构地区：[1]School of Chemistry and Chemical Engineering, Sun Yat-sen University

出　　处：《Chinese Chemical Letters》2016年第2期283-286,共4页中国化学快报（英文版）

摘　　要：In this study,a novel class of histidine Schiff base silver（Ⅰ） complexes derived from salicylaldehyde,1a-9a,was found to be an effective inhibitor of α-glucosidase.The results of this study showed that the newly synthesized complexes inhibited α-glucosidase through noncompetitive mechanisms;the IC50values were ranging from 0.00431 μmol L ~1 to 0.492 μmol L ~1.The structure-activity relationship was established as well.These results demonstrated that compound 7a,5-nitro salicylaldehyde Schiff base silver complex,is the most promising α-glucosidase inhibitor with the lowest IC50 value,which could be exploited as a drug candidate to alleviate postprandial hyperglycemia in the treatment of type II diabetes mellitus.This research provided a catalyst-free,simple,and environmentally benign reaction to synthesize compounds using mechanochemistry.In this study,a novel class of histidine Schiff base silver（Ⅰ） complexes derived from salicylaldehyde,1a-9a,was found to be an effective inhibitor of α-glucosidase.The results of this study showed that the newly synthesized complexes inhibited α-glucosidase through noncompetitive mechanisms;the IC50values were ranging from 0.00431 μmol L ~1 to 0.492 μmol L ~1.The structure-activity relationship was established as well.These results demonstrated that compound 7a,5-nitro salicylaldehyde Schiff base silver complex,is the most promising α-glucosidase inhibitor with the lowest IC50 value,which could be exploited as a drug candidate to alleviate postprandial hyperglycemia in the treatment of type II diabetes mellitus.This research provided a catalyst-free,simple,and environmentally benign reaction to synthesize compounds using mechanochemistry.

关 键 词：Α-GLUCOSIDASE Histidine schiff base silver（Ⅰ） complexes Type Ⅱ diabetes mellitus 

分 类 号：O641.4[理学—物理化学] TQ460.1[理学—化学]