电化学免疫传感器在肿瘤标志物检测中的应用  

Application of electrochemical immunosensors for tumor markers detection

作　　者：冯德香[1] 尉艳[1] 黄勤安[1] 

机构地区：[1]皖南医学院化学教研室,芜湖241002

出　　处：《分析试验室》2016年第3期363-372,共10页Chinese Journal of Analysis Laboratory

基　　金：国家自然基金项目(21105073)资助

摘　　要：针对电化学免疫传感器研究的关键问题传感器的灵敏度,将具有优异性质的纳米材料及纳米复合材料应用于传感器敏感界面构建和电化学活性纳米探针的设计去增强检测信号方面进行总结,并将电极表面生物识别层的固定方法及电化学免疫传感器对多肿瘤标志物的联合检测应用进行了的综述,且对电化学免疫传感器的应用前景进行展望。Trace amounts of the tumor markers detection play an important role in clinical diagnosis. Compared with other immunoassays,electrochemical immunosensors are of great interest because of excellent properties. An important issue of the electrochemical immunosensors is focused on the sensitivity enhancement. Thus,this review summarizes nanomaterial and nanomaterial nanocomposites with a series of excellent properties to construct the sensitive electrode interface and electroactive nanoprobe for signal amplification. We also review the way to immobilize the recognition layer onto electrodes and multiplexing detection. Further study and prospect are envisioned.

关 键 词：电化学免疫传感器 肿瘤标志物 综述 

分 类 号：O657.1[理学—分析化学]