老年慢性肾衰竭认知功能障碍患者血清白介素-6、C反应蛋白水平变化  

Change of inflammatory factors serum IL-6 and CRP in cognitive impairment in older chronic renal failure patients

作　　者：牛铁明[1] 黄葵[2] 熊焰[1] 

机构地区：[1]沈阳市红十字会医院肾内科,辽宁沈阳110013 [2]沈阳市红十字会医院老年医学科,辽宁沈阳110013

出　　处：《国际泌尿系统杂志》2016年第2期219-222,共4页International Journal of Urology and Nephrology

基　　金：辽宁省自然科学基金（201102207）

摘　　要：目的 通过老年慢性肾衰竭认知功能障碍患者血清白介素-6、C反应蛋白水平的变化,分析老年慢性肾衰竭认知功能障碍与血清白介素-6、C反应蛋白之间的关系,探讨老年慢性肾衰竭患者认知功能的影响因素.方法 选择45例老年慢性肾衰竭患者,进行简明精神状态评估量表（Mini-mental state examination MMSE）评估,根据MMSE评分结果分为认知功能障碍组和认知功能正常组.检测白介素-6、C反应蛋白水平,检测血肌酐、尿素氮、血红蛋白、血脂、钙、磷、甲状旁腺素等指标,计算肌酐清除率.结果 本组老年慢性肾衰竭患者存在认知功能障碍者为28例;认知功能障碍组血清白介素-6、C反应蛋白水平显著高于认知功能正常组;与认知功能正常组比较,年龄、慢性肾衰竭病程、血肌酐、血红蛋白、肌酐清除率的差异具有统计学意义（P＜0.05）;相关分析表明血清白介素-6水平与MMSE评分成显著负相关（P＜0.05）.结论 老年慢性肾衰竭患者认知功能障碍发生率较高,微炎症反应与老年慢性肾衰竭认知障碍密切相关.Objectives To investigate the diversity of serum IL-6 and CRP in older chronic renal failure（CRF） patients with cognitive impairment.Methods 45 older CRF patients were enrolled in this study.（Mini-mental state examination MMSE）were performed.The objects were divided into cognitive damage group and normalcognitive function group according to the presence or absent of cognitive impairment.Serum interleukin-6 （IL-6） and creative protein（CRP） were measured as markers of chronic inflammation.Creatinine （Cr）,Hemoglobin （Hb）,Parathyroid Hormone （PTH）,Creatinine clearance rate（Ccr） and other biochemical indicators were also measured in all subjects.Results IL-6 and CRP levels in the cognitive damage group were higher than that in nomal cognitive function group,and there were significant differences （P 〈 0.05）;Age,CRF course,Cr,Hb,PTH,Ccr were significant different in two groups（P 〈0.05）;The IL-6 levels of patients were negatively correlated with the score of MMSE.Conclusions There is high prevalence of cognitive impairment in older CRF patients and inflammation is associated with cognitive impairment in older CRF patients.

关 键 词：肾功能衰竭 慢性 认知障碍 白细胞介素6 C反应蛋白质 

分 类 号：R692.5[医药卫生—泌尿科学] R749[医药卫生—外科学]