292株凝固酶阴性葡萄球菌的临床分布及耐药性  

Distribution and drug resistance of 292 strains of coagulase negative Staphylococus

作　　者：周小梅[1] 游明园 廖小平[1] 谭庆[1] 孙煦勇 

机构地区：[1]解放军第303医院,广西南宁530021 [2]移植医学研究院

出　　处：《中国消毒学杂志》2016年第3期255-257,共3页Chinese Journal of Disinfection

基　　金：中华医院感染控制研究基金(ZHYG2014-0007)

摘　　要：目的了解某医院住院患者感染凝固酶阴性葡萄球菌分布特征及其耐药情况,为控制感染提供依据。方法采用回顾性调查方法,对某医院临床病原学标本检验诊断的凝固酶阴性葡萄球菌(CNS)感染患者的临床资料进行统计分析。结果该医院连续3年从临床送检病原学标本中共检出葡萄球菌属651株,其中CNS 292株,占葡萄球菌属的44.9%。在CNS中,溶血葡萄球菌、表皮葡萄球菌和人型葡萄球菌的构成比依次为37.7%、29.1%和9.9%,其他葡萄球菌占23.3%。临床分离的CNS对药敏试验的26种抗菌药物中耐药率超过50%的达21种,仅对利奈唑胺全部敏感,对呋喃妥因、替考拉宁和万古霉素比较敏感。结论该医院临床分离的CNS比例大,耐药严重,应加强监测和药敏试验,指导抗菌药物的选择和应用。Objective To investigate the distribution characteristic of coagulase- negative Staphylococcus and its drug resistance in a hospital,and provide evidence for clinical infection control. Methods By means of retrospective survey,the data of clinical etiologic specimens infected by coagulase negative Staphylococcus（ CNS） in a certain hospital were analyzed.Results In continuous 3 years,651 strains of Staphylococcus from the clinical etiologic samples were detected,which include 292 strains of coagulase- negative Staphylococuswere（ accounted for 44. 9%）. Among the CNS strains,Staphylococus haemolyticus,Staphylococusepidermidis and Staphylococcus hominis were 37. 7%,29. 1% and 9. 9% respectively,and the other Staphylococcus accounted for 23. 3%. In the antimicrobial susceptibility test,21 of the clinical isolated CNS strains were resistant to more than 50% of the 26 kinds of antibacterial agents. They were all sensitive to only the rina thiazole. And they were quite sensitive to nitrofurantoin,teicoplanin and vancomycin. Conclusion The coagulase negative isolates Staphylococci has a large proportion in the hospital clinical samples and drug resistance are serious. Monitoring and drug sensitivity test should be strengthened,and more instructions should be made about the antibacterial drug selection and application.

关 键 词：凝固酶阴性葡萄球菌 耐药性 医院感染 分布特点 

分 类 号：R378[医药卫生—病原生物学]