几种天然吡喃酮衍生物的抗肿瘤活性分析  

Anti-tumor Activity Anaysis of Several Natural Pyrones Derivatives

作　　者：郑旭升[1] 李慧慧[2] 李琦[2] 唐宇[2] 王毅刚[1] 许传莲[1] 

机构地区：[1]浙江理工大学生命科学学院,杭州310018 [2]天津大学药学院,天津300072

出　　处：《浙江理工大学学报（自然科学版）》2016年第1期99-102,115,共5页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：国家自然科学基金项目(81272687);浙江省生物学重中之重学科开放基金项目(11610032211201/002/008)

摘　　要：通过对几种天然吡喃酮衍生物的抗肿瘤活性分析,获得具有较强抗肿瘤活性的该类化合物。利用MTT法检测6种结构经修饰与改造的天然吡喃酮类化合物对多种肿瘤细胞的细胞毒性,结果显示化合物LiQ-1与LiH-Ⅳ-80的抗肿瘤活性最为显著。利用化合物LiQ-1分析其对人红白血病K562细胞的生长影响,结果呈剂量依赖关系。通过对化合物的结构分析比较证明,对于化合物LiH-IV-80、LiH-IV-50-2和LiH-III-122-2,在7-位形成的内酯环对抑制肿瘤细胞增殖有着重要的影响,而对于化合物LiQ-1、LiQ-2和LiQ-4,4-位OH对化合物的抗肿瘤活性影响较大。Natural pyrones derivatives with stronger anti-tumor activity were gained through antitumor activity analysis of several such compounds.MTT was used to detect the cytotoxicity of 6natural pyrone compounds on tumor cells after structural modification and reconstruction.The results show that the antitumor activity of LiQ-1and LiH-Ⅳ-80 is significantly strong.LiQ-1was used to analyze its infleunce on erythroleukemia K562 cell growth,and the result presented dose-dependent relaitonship.Through analysis and comparison of compound structure,it is proven that for LiH-IV-80,LiH-IV-50-2and LiH-III-122-2,lactonic ring formed in 7-position plays an important role on tumor inhibition cell proliferation.For LiQ-1,LiQ-2and LiQ-4,4-position OH has a great affect on tumor activity.

关 键 词：天然吡喃酮 结构修饰 MTT法 抗肿瘤活性 

分 类 号：R285.5[医药卫生—中药学]