三七药性菌质正丁醇部位化学成分研究(Ⅰ)  

Chemical Constituents of n-butanol Fraction of Notoginseng Medicinal Fungal Substance(Ⅰ)

作　　者：王新闻[1] 刘晓莉[1] 丁彩凤 邱智东[1] 徐伟[1] 

机构地区：[1]长春中医药大学,长春130117

出　　处：《中国实验方剂学杂志》2016年第7期89-92,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2012BAI29B00)

摘　　要：目的:对三七药性菌质中正丁醇部位的化学成分进行研究。方法:采用系统溶剂萃取、D101大孔吸附树脂、硅胶柱色谱、开放式ODS柱色谱、半制备液相等方法进行分离纯化,通过化学性质和波谱数据确定化合物的结构。结果:从三七药性菌质正丁醇部位分离得到6个化合物,分别为人参皂苷Rk3(1),拟人参皂苷RT2(2),人参皂苷Rg3(3),24(R)-拟人参皂苷GQ(4),人参皂苷Rd(5),绞股蓝皂苷LXIX(6)。结论:化合物2和化合物4为首次从三七植物中分离得到,所有化合物均为首次从三七药性菌质中分离得到。Objective： To investigate the chemical constituents of n-butanol fraction of notoginseng medicinal fungal substance. Method： The compounds were separated and purified through the system solvent extraction, D101 macroporous adsorbent resin, silica gel column chromatography, open ODS column chromatography,and semi-preparative liquid chromatography. The structures of the compound were identified by chemical properties and spectroscopic data. Result： Six compounds were separated from n-butanol fraction of notoginseng medicinal fungal substance and identified as ginsenoside Rk3（ 1）,pseudoginsenoside RT2（ 2）,ginsenoside Rg3（ 3）,24（ R）-pseudoginsenoside GQ（ 4）,ginsenoside Rd（ 5）,and gypenoside LXIX（ 6）.Conclusion： Compound 2 and compound 4 were isolated from notoginseng for the first time,and all compounds were isolated from notoginseng medicinal fungal substance for the first time.

关 键 词：三七药性菌质 正丁醇部位 拟人参皂苷RT2 24(R)-拟人参皂苷GQ 

分 类 号：R284.1[医药卫生—中药学]