细菌耐药性与抗生素增效剂开发  

Bacterial Resistance and Antibiotics Synergist Development

作　　者：陈代杰 

机构地区：[1]中国医药工业研究总院,上海201203

出　　处：《上海应用技术学院学报（自然科学版）》2016年第1期1-9,共9页Journal of Shanghai Institute of Technology: Natural Science

基　　金：国家自然科学基金面上项目(81273413);"重大新药创制"国家科技重大专项资助(2012ZX09201101-008)

摘　　要：细菌耐药性是导致现代抗生素使用药效下降的最主要原因之一,几乎所有结构类别的抗生素能够诱导不同的细菌产生耐药响应.综述了细菌产生耐药性的主要途径和抗生素增效剂的研究进展.从解除耐药能力和拮抗耐药靶点两方面总结了抗生素增效剂的研发策略.展示抗生素增效剂广阔的应用前景.Bacterial resistance is one of the most important reasons for the decline in drug efficacy of modern antibiotics,and almost all antibiotics can induce the bacteria resistance.The main pathway of different bacteria resistances was expounded in details.Based on the analysis of the different mechanisms destroying bacteria resistances and killing the machine tools of making the bacteria resistances,a new synergist strategy for developing new pharmaceutical against bacteria resistance was proposed.The wide prospect of the application of antibiotic synergist was presented.

关 键 词：耐药性 抗生素 增效剂 

分 类 号：R978[医药卫生—药品]