Cyclaniliprole的合成与杀虫活性  

Synthesis and Insecticidal Activity of Cyclaniliprole

作　　者：英君伍 罗焕 宋玉泉 李斌 杨辉斌 

机构地区：[1]沈阳中化农药化工研发有限公司,新农药创制与开发国家重点实验室,沈阳110021

出　　处：《现代农药》2016年第2期28-31,共4页MODERN AGROCHEMICALS

基　　金：“十二·五”国家科技支撑计划项目(2011BAE06B01)

摘　　要：以邻硝基苯甲酸为起始原料,经酯化、还原、氯化、溴化、水解、酰化以及缩合反应制得关键中间体2-氨基-3-溴-5-氯-N-（1-环丙基乙基）苯甲酰胺,该中间体进一步与3-溴-1-（3-氯吡啶-2-基）-1H-吡唑-5-甲酰氯反应合成cyclaniliprole。目标化合物结构经MS和-1H NMR确证。杀虫活性测试结果表明,cyclaniliprole对小菜蛾及黏虫具有优异的杀虫活性,在10 mg/L质量浓度下对小菜蛾和黏虫的防效分别为88.2%和100%。The synthetic method of cyclaniliprole was introduced in this paper. First,2-amino-3-bromo-5-chloro-N-（1-cyclopropyl-ethyl）benzamide was synthesized using 2-nitrobenzoic acid as starting material,by steps of esterification,reduction,chlorination,bromination,hydrolysis,acylation and condensation. Then,cyclaniliprole was prepared from 2-amino-3-bromo-5-chloro-N-（1-cyclopropyl-ethyl）benzamide and 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carbonyl chloride. The structure of the target compound was confirmed by MS and1 H NMR. Indoor insecticidal activity test showed that cyclaniliprole had excellent insecticidal activities against diamond back moth and army worm,with the control effects of 88.2% and 100% at the concentration of 10 mg/L.

关 键 词：cyclaniliprole 2-氨基-3-溴-5-氯-N-(1-环丙基乙基)苯甲酰胺 合成 杀虫活性 

分 类 号：TQ453[化学工程—农药化工]