Association of late-life changes in blood pressure and cognitive status  

作　　者：Maria E Lacruz Daniel Tiller Alexander Kluttig Karin H Greiser Sebastian Nuding Karl Werdan Johannes Haerting 

机构地区：[1] Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany [2] German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany [3] Department of Medicine III, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany

出　　处：《Journal of Geriatric Cardiology》2016年第1期37-43,共7页老年心脏病学杂志（英文版）

摘　　要：BackgroundDisagreement exists on the association between changes in blood pressure and cognitive impairment. We aimed to ex-amine whether 4-year changes in systolic and diastolic blood pressure （SBP and DBP） are associated with cognitive status in a representative sample of older men and women.MethodsAnalysis of longitudinal data from 854 participants of a population-based German sample （aged 60-87 years） was performed with standard cognitive screening and blood pressure measurements. Effects of changes in SBP and DBP （10 mmHg and 5 mmHg respectively as unit of regression effect measure） on cognitive status were evaluated using non-parametric and lin-ear regression modeling.ResultsNo clear associations were seen between changes in SBP or in DBP and cognitive scores. Small effects were found after stratification for sex and hypertension awareness. Specifically, larger decreases in SBP were associated with higher cogni-tive scores in those men aware of their hypertension （10 mmHg decrease in SBP,b =-0.26, 95% CI：-0.51 to-0.02） and men with con-trolled hypertension （10 mmHg decrease in SBP,b =-0.44, 95% CI：-0.92 to-0.03）. Additionally larger increases in DBP were associated with higher cognitive scores in men with controlled hypertension （5 mmHg increase in DBP,b = 0.67, 95% CI： 0.19-1.15）. For women aware of their hypertension, larger decreases in DBP were associated with higher cognitive scores （5 mmHg decrease in DBP,b =-0.26; 95%CI：-0.51 to-0.01）.ConclusionsChanges in blood pressure were only weakly associated with cognitive status. Specifically, decreases in SBP were associated with higher cognitive scores in men aware of their hypertension and especially those that were medically controlled.

关 键 词：Blood pressure Cognitive status The elderly 

分 类 号：R3[医药卫生—基础医学]