酚妥拉明对小鼠缺氧耐受力的影响  

Effects of phentolamine on tolerance to anoxia in mice

作　　者：张政[1] 李慧娟[1] 韩婧凤 徐亭亭[1] 陈鹏[1] 叶子铭[1] 陶敏[1] 王丹[2] 

机构地区：[1]徐州医学院麻醉学院2012级2班,江苏徐州221004 [2]徐州医学院麻醉药理学教研室

出　　处：《徐州医学院学报》2016年第2期91-92,共2页Acta Academiae Medicinae Xuzhou

基　　金：江苏省高校自然科学基础研究项目（09KJB320019）

摘　　要：目的观察酚妥拉明对小鼠缺氧耐受力的影响。方法小鼠腹腔注射生理盐水或酚妥拉明（2mg·kg^（-1））15min后，测定小鼠常压耐缺氧存活时间、亚硝酸钠中毒存活时间和急性脑缺血性缺氧张口喘气时间。结果酚妥拉明会显著缩短小鼠的常压耐缺氧存活时间（P〈0．01）和亚硝酸钠中毒存活时间（P〈0．05），对急性脑缺血性缺氧张口喘气时间影响不大（P〉0．05）。结论酚妥拉明会降低小鼠常压和亚硝酸钠中毒的缺氧耐受力。Objective To observe the effects of phentolamine on tolerance to anoxia in mice. Methods Mice were intraperitoneally injected with normal saline or phentolamine （2 mg · kg^（-1 ））. Fifteen minutes later, the survival duration under anoxic conditions with normal pressure, the survival duration after sodium nitrite toxieation, and the duration of gasp under anoxie conditions due to acute cerebral ischemic were recorded. Results Phentolamine could remarkably shorten the survival duration of mice under anoxic conditions with normal air pressure （P 〈0.01 ） and the survival dura- tion after sodium nitrite poisoning （ P 〈 0. 05 ）, but produce little impact on the duration of gasp under anoxic conditions due to acute cerebral ischemic （P 〉0. 05 ）. Conclusion Phentolamine can weaken tolerance to anoxia in mice under normal pressure and after sodium nitrite poisoning.

关 键 词：酚妥拉明 缺氧 亚硝酸钠中毒 急性脑缺血性缺氧 小鼠 

分 类 号：R972[医药卫生—药品]