人类基因多态性与移植后巨细胞病毒感染相关性研究进展  

Progress on the association between human gene polymorphisms and cytomegalovirus infection after transplantation

作　　者：魏巴金[1,2] 周琳[1] 

机构地区：[1]浙江大学医学院附属第一医院器官移植重点实验室,杭州310003 [2]浙江大学医学院附属第一医院乳腺疾病诊治中心,杭州310003

出　　处：《中华移植杂志（电子版）》2016年第1期45-48,共4页Chinese Journal of Transplantation(Electronic Edition)

摘　　要：CMV是一种疱疹DNA病毒,一般正常人群可以携带,但不引起临床症状。移植后合并CMV感染在供者CMV阳性而受者CMV阴性(D+/R-)时发生率较高,轻者可能引起轻微无症状感染,重者可能引起严重器官功能衰竭甚至死亡。常见的预防措施因为药物不良反应和经济问题而无法全面应用。在过去的10年里,有很多探讨人类基因多态性和移植后CMV感染、再燃和相关组织疾病等之间关系的研究,但结果并不一致。本文系统地阐述了目前人类基因多态性与移植后CMV感染的相关性研究,并根据移植类型(包括肝移植、肾移植、心肺移植、造血干细胞移植和实体器官移植),有助于掌握目前的研究进展,为未来研究方向提供一定的参考。Cytomegalovirus belonged to herpes virus group, which could be carried by health people. The patients with transplantation often suffered from the deficiency of innate and adaptive immune. Therefore, cytomegalovirus relative diseases were extremely common after transplantation, especially in （ D ＋ R -/D - R ＋ ） group. The clinical outcomes fluctuated between mild asymptomatic infection and multiple organ dysfunction syndromes. The benefit of prophylactic anti-virus drugs should be measured before transplantation for their own limitations （adverse side effects and financial burdens）. In the past 10 years, many single nucleotide polymorphisms in human genes had been analyzed to explore their relationships with cytomegalovirus infection, reactivation and tissue relative diseases, but the results were not consistent. Our study tried to illustrate and classify those associations by genes and transplantations. It would help to understand the progress of current researches and show the potential direction in the future.

关 键 词：基因多态性 巨细胞病毒 移植 

分 类 号：R617[医药卫生—外科学]