乌司他丁辅助治疗小儿重症肺炎疗效观察  

Observation of the effect of ulinastatin in the treatment of children with severe pneumonia

作　　者：李树青[1] 孙雪丽[1] 王执勇[1] 韩炳鑫[1] 沈玲[1] 吴春莲[1] 

机构地区：[1]潍坊市妇幼保健院儿一科,山东省潍坊261011

出　　处：《中国基层医药》2016年第6期877-880,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察乌司他丁（UTI）辅助治疗小儿重症肺炎的临床疗效。方法将86例重症肺炎患儿按住院证号单号和双号分为两组，治疗组45例，对照组41例。治疗组在其他治疗相同的情况下，给UTI治疗，5000U·kg^-1·次^-1，2次／d，连用7d。期间观察记录体温降至正常的时间、呼吸困难改善及消失时间、肺部哕音消失时间及住院时间。治疗7d后进行疗效判定。结果治疗组显效21例、有效21例、无效3例，总有效率为93．33％，对照组显效17例、有效15例、无效9例，总有效率为78．04％，两组总有效率差异有统计学意义（χ^2=4．17，P〈0．05）。治疗组体温降至正常时间、呼吸困难改善及消失时间、肺部哕音消失时间及住院天数分别为（3．37±1．51）d、（3．12±1．72）d、（7．15±2．45）d、（10．75±2．47）d，对照组分别为（5．02±1．78）d、（4．82±1．51）d、（9．08±2．85）d、（13．22±2．85）d，两组差异均有统计学意义（t=4．71、4．91、3．42、4．41，均P〈0．01）。结论UTI辅助治疗小儿重症肺炎在改善临床症状方面有较好的疗效，值得推广应用和进一步研究。Objective To observe the effect of ulinastatin in the treatment of children with severe pneumonia. Methods 86 children with severe pneumonia were divided into two groups according to the hospital card number： treatment group（ n = 45 ） and control group （n = 41 ）. All of them were given routine treatment, while the patients of the treatment group were given ulinastatin （5 000 U ; kg^-1 . time^-l, 1-2times/d ,7d） in addition. The time of temperature drop to normal, the time of dyspnea improve, the time of dyspnea disappear, the time of lung rale disappear and length of hospital stay were observed. Then, the therapeutic effect was evaluated after treatment for 7 days. Results The treatment group had 21 cases excellence, 21 cases improvement and 3 cases failure, the total effective rate was 93.33% ,the control group had 17 cases excellence, 15 cases improvement and 9 cases failure,the total effective rate was 78.04%, there was significant difference between the two groups （χ^2 = 4.17, P 〈 0.05 ）. The time of temperature drop to normal, the time of dyspnea .improve, the time of dyspnea disappear, the time of lung tale disappear and length of hospital stay in the treatment group were （3.37 ± 1.51 ） d, （ 3.12 ± 1.72） d, （7.15 ± 2.45 ） d, （ 10.75 ± 2.47 ） d, respectively, which in the control group were （5.02 ±1.78 ） d, （4.82 ±1.51 ） d, （ 9.08 ±2.85 ） d, （ 13.22 ± 2.85 ） d, there were significant differences between the two groups （ t = 4.71,4.91, 3.42,4.41, all P 〈 0.01 ）. Conclusion Ulinastatin has good effect on children with severe pneumonia. It has value in application.

关 键 词：乌司他丁 肺炎 儿童 

分 类 号：R725.6[医药卫生—儿科]