某院鲍曼不动杆菌耐药率与抗菌药物使用量的相关性分析  

Correlation between antimicrobial resistance of Acinetobacter baumannii and utilization of antimicrobial agents in our hospital

作　　者：张楠[1] 武新颖[2] 王俊文[3] 杨慧鹃 夏文斌[1] 

机构地区：[1]清华大学附属北京市垂杨柳医院药学中心,北京市100022 [2]清华大学附属北京市垂杨柳医院感染控制部,北京市100022 [3]清华大学附属北京市垂杨柳医院检验科,北京市100022

出　　处：《中国基层医药》2016年第6期897-900,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的分析清华大学附属北京市垂杨柳医院鲍曼不动杆菌耐药率与抗菌药物使用情况的相关性，为临床合理使用抗菌药物提供依据。方法回顾性调查该院2010-2014年分离出的2194株鲍曼不动杆菌的耐药率以及抗菌药物的使用情况，计算用药频度（DDDs）及药物利用指数（DUI），对鲍曼不动杆菌耐药率与抗菌药物DDDs、DUI进行Pearson相关性分析。结果该院鲍曼不动杆菌对亚胺培南／西司他丁的耐药率与其DDDs、DUI均呈显著正相关（r=0．991，0．994，P〈0．01），对头孢吡肟的耐药率与其DDDs呈显著正相关（r=0．934，P=0．020），对阿米卡星的耐药率与依替米星的DDDs呈显著正相关（r=0．931，P=0．022），对左氧氟沙星的耐药率与其DUI呈显著负相关（r=-0．986，P=0．002）。结论该院鲍曼不动杆菌对常用抗菌药物耐药率高，其耐药率与部分抗菌药物使用量存在相关性。Objective To analyze the correlation between the resistance of Acinetobacter baumannii and the utilization of antimicrobial agents in the hospitalized patients of Beijng Chuiyangliu Hospital, and provide the basis for clinical rational use antimicrobial agents. Methods A retrospective analysis was conducted for the drug resistance rate and specimen source of the 2 194 strains of Acinetobacter banmannii from 2010 to 2014 in the hospital and DDDs/DUI of antimicrobial agents was analyzed by Pearson correlation. Results The resistance rate of Acinetobacter banmannii was positively correlated with the DDDs and DUI of imipenem/cilastatin（ r = 0. 991,0. 994 , all P 〈 0.01 ）, and was positively correlated with the DDDs of cefepime （ r = 0.934,P = 0.020）. The resistance rate of Acinetobacter baumannii to amikacin was positively correlated with the DDDs of etimicin （r = 0.931, P = 0.022）. The resistance rate of Acinetobacter baumannii was negatively correlated with the DUI of levofloxacin （ r = - 0. 986, P = 0. 002 ）.Coachtsion The resistance rate of Acinetobacter baumannii was high and there was correlation between the drug resistance and the utilization of Some antimicrobial agents.

关 键 词：鲍曼不动杆菌 抗菌药物 耐药率 用药频度 相关性分析 

分 类 号：R96[医药卫生—药理学]