痤疮患者血清H_2S水平检测及与IL-6和TNF-α水平的相关性  

Detection of hydrogen sulfide and its correlation with interleukin 6 and tumor necrosis factor-α in patients with acne

作　　者：王玉[1] 黄霞[1] 余晶晶[1,2] 

机构地区：[1]湖北省十堰市人民医院皮肤科,442000 [2]湖北医药学院,442000

出　　处：《中国麻风皮肤病杂志》2016年第3期147-149,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测痤疮患者血浆H2S水平及确定与IL-6和TNF-α水平的相关性。方法:采用亚甲基染色法检测67例痤疮患者(轻度31例、中度21例、重度15例)及20名健康体检者血清H2S水平,ELISA检测血清IL-6和TNF-α水平。结果:痤疮患者血清H2S平均水平为(13.79±4.19)μmmol/L,显著低于对照组的(22.23±4.52)μmmol/L(P<0.001);血清IL-6及TNF-α平均水平分别为(89.72±31.68)pg/mL及(61.17±23.81)pg/mL,高于对照组的(27.32±4.26)pg/mL和(22.73±14.33 pg/mL)(P<0.001)。痤疮患者血浆H2S水平与IL-6和TNF-α浓度均呈显著负相关(均P<0.001)。结论:血浆H2S可能参与痤疮炎症的发病过程。Objective： To detect the level of hydrogen sulfide（ H2S） and to determine the relationship between serum H2 S level and the levels of IL- 6 and TNF- α among the patients with acne vulgaris. Methods：The level of H2 S in 67 patients with acne vulgaris（ 31 patients with mild acne,21 with moderate acne and 15 with severe acne） and 20 normal controls was detected by methylene blue staining. The level of IL- 6 and TNF- α were detected by ELISA. Results： The average level of H2 S in the patients with acne was（ 13. 79 ±4. 19） μmmol / L,which was lower than that in controls（ 22. 23 ± 4. 52） μmmol / L. The average levels of IL-6 and TNF- α were（ 89. 72 ± 31. 68） pg / mL and（ 61. 17 ± 23. 81） pg / mL,which was higher than those in controls（ 27. 32 ± 4. 26） pg / mL and（ 22. 73 ± 14. 33） pg / mL. The H2 S level of patients was negatively correlated with the levels of IL- 6 and TNF- α（ P 〈0. 001）. Conclusion： H2 S may be associated with the inflammation reaction in the course of acne.

关 键 词：痤疮 硫化氢 IL-6 TNF-Α 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]