颗粒溶素在皮肤病中的研究进展  

Update of granulysin in some skin diseases

作　　者：邱小惠[1] 纪超[1] 程波[1] 

机构地区：[1]福建医科大学附属第一医院皮肤科,350005

出　　处：《中国麻风皮肤病杂志》2016年第3期186-188,共3页China Journal of Leprosy and Skin Diseases

摘　　要：颗粒溶素是一种溶细胞和促炎症分子,表达于活化的人类细胞毒T细胞(CTLs)和自然杀伤(NK)细胞,参与Stevens-Johnson综合征/中毒性坏死性表皮松解症(SJS/TEN)、银屑病、毛囊炎、扁平苔藓和病毒性水疱等多种皮肤病的发生发展,尤其在SJS/TEN发病过程中是引起角质形成细胞凋亡的重要诱导物。本文就颗粒溶素在皮肤病早期诊断、病情监测及治疗中的应用作一综述。Granulysin,a cytolytic and proinflammatory molecule which is produced by activated human cytotoxic T lymphocytes（ CTLs） and natural killer（ NK） cells plays a significant role in the development of multiple skin diseases such as Stevens- Johnson syndrome / toxic epidermal necrosis（ SJS / TEN）,psoriasis,folliculitis,lichen planus and viral vesicles,etc. Especially granulysin is a key mediator for disseminating keratinocyte apoptosis in SJS / TEN. Studies on application of granulysin in skin disease including early diagnosis,illness monitoring and treatment was reviewed in the paper.

关 键 词：颗粒溶素 中毒性坏死性表皮松解症 

分 类 号：R751[医药卫生—皮肤病学与性病学]