慢性NK细胞增殖性疾病1例并文献复习  

A case report of chronic lymphoproliferative disorders of natural killer cells and literature review

作　　者：李国辉[1] 陈任安[1] 范玉贞[2] 杨健[1] 秦炜炜[1] 尹郸丹[1] 任俊[1] 刘利[1] 

机构地区：[1]第四军医大学唐都医院血液科,西安710038 [2]第四军医大学唐都医院中医科

出　　处：《临床血液学杂志》2016年第2期240-243,共4页Journal of Clinical Hematology

基　　金：国家自然科学基金青年科学基金项目(No:81100354)

摘　　要：慢性NK细胞增殖性疾病是起源于成熟NK细胞系的恶性淋巴细胞增殖性疾病,作为2008年WHO关于淋巴造血组织肿瘤分类中的独立类型,其发病率极低。我们诊治慢性NK细胞增多症（CNKL）1例,将其临床资料报告如下,并结合文献进行讨论。1病例资料患者,女,64岁,因＂间断乏力、气短1个月＂就诊于我院。患者1个月前无明显诱因出现乏力、气短,于航空医院查血常规示：WBC 30.64×10~9/L,HGB 129 g/L,RBC 4.54× 102/L,PLT 231 ×109/ L,LYMPH 27. 50 × 109/L。The phenomenon of persistent natural killer（NK）cell lymphocytosis has been recognized as the provisional diagnostic entity＇chronic lymphoproliferative disorder of natural killer cells＇（CLPD-NK）in the WHO classification of hematopoietic tumors.However,disease recognition is problematic because NK cells lack a uniquely rearranged antigen receptor gene（such as T-cell receptor）to serve as a marker of clonal cellular expansion and to facilitate distinction from reactive processes.The paucity of literature suggests that CLPD-NK is rare.Here we report a case of CLPD-NK and discuss it with the relevant literatures.

关 键 词：慢性NK细胞增殖性疾病 大颗粒淋巴细胞 自然杀伤细胞 

分 类 号：R557.4[医药卫生—血液循环系统疾病]