Synthesis and Biological Activities of 10-Substituted 9-Aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones  

作　　者：汪芳明 胡兵相 陈传祥 周泽宇 鲍丹 陈立庄 

机构地区：[1]School of Environmental and Chemical Engineering,Jiangsu University of Science and Technology

出　　处：《Chinese Journal of Structural Chemistry》2016年第3期442-448,共7页结构化学（英文）

基　　金：supported by National Natural Science Foundation of China for Young Scholars(No.21201087);Natural Science Foundation of Jiangsu Province(No.BK20131244&BK2012699);Jiangsu Overseas Research&Training Program for University Prominent Young&Middle-aged Teachers and Presidents;a start-up grant from Jiangsu University of Science and Technology of China

摘　　要：A series of 10-substituted 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8（2H,5H）-dione derivatives 2 were synthesized by a two-step reaction.All the compounds were characterized by IR,MS,and ^1H NMR.Crystals of 1a and 2c were obtained and determined by X-ray single-crystal diffraction.Crystal data of 1a：C_（20）H_（22）O_5,orthorhombic system,space group Pbcn,a = 15.8888（19）,b = 18.228（2）,c = 11.6926（13） A,V = 3386.4（7） A^3,Z = 8,F（000） = 1456,Dc = 1.343 g/cm^3,R = 0.0456 and w R = 0.1600.Crystal data of 2c：C_（26）H_（24） Cl NO_3,monoclinic system,space group P2_1/n,a = 8.628（2）,b = 10.912（3）,c = 22.425（7） A,β = 90.786（4）°,V = 2111.1（10） A^3,Z = 4,F（000） = 912,D_c = 1.365 g/cm^3,R = 0.0613,and w R = 0.1196.The results of biological experiments show that compounds 2b and 2c could inhibit the proliferation of Hep G2 cells.A series of 10-substituted 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8（2H,5H）-dione derivatives 2 were synthesized by a two-step reaction.All the compounds were characterized by IR,MS,and ^1H NMR.Crystals of 1a and 2c were obtained and determined by X-ray single-crystal diffraction.Crystal data of 1a：C_（20）H_（22）O_5,orthorhombic system,space group Pbcn,a = 15.8888（19）,b = 18.228（2）,c = 11.6926（13） A,V = 3386.4（7） A^3,Z = 8,F（000） = 1456,Dc = 1.343 g/cm^3,R = 0.0456 and w R = 0.1600.Crystal data of 2c：C_（26）H_（24） Cl NO_3,monoclinic system,space group P2_1/n,a = 8.628（2）,b = 10.912（3）,c = 22.425（7） A,β = 90.786（4）°,V = 2111.1（10） A^3,Z = 4,F（000） = 912,D_c = 1.365 g/cm^3,R = 0.0613,and w R = 0.1196.The results of biological experiments show that compounds 2b and 2c could inhibit the proliferation of Hep G2 cells.

关 键 词：xanthenes acridones synthesis crystal structure biological activity 

分 类 号：O626[理学—有机化学]