178例脉络宁注射液不良反应的文献分析  

Literature Analysis of 178 Cases of Adverse Drug Reactions Induced by Mailuoning Injection

作　　者：孙丽[1] 唐汉武[1] 

机构地区：[1]广州中医药大学第三附属医院,广东广州510000

出　　处：《中国药物警戒》2016年第3期169-172,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨脉络宁注射液所致不良反应（ADR）的一般规律及特点,为临床合理用药提供参考。方法检索1992-2015年国内公开发表的有关脉络宁注射液致不良反应的个案报道,并将收集到的178例ADR信息进行统计分析。结果脉络宁注射液所致的ADR与性别无关,多发生于41-65岁的中年患者;用药30 min内发生ADR占62.92%,以全身性损害及呼吸系统损害为主;临床表现主要为呼吸困难、过敏性休克;有2例患者死亡,其余患者经对症治疗后均恢复正常。结论脉络宁注射液可致严重ADR及说明书中未描述的ADR,应加强用药监测,发生ADR时及时处理,以确保患者用药安全。Objective To analyze general regularity and characteristics of Mailuoning injection-induced ADRs, and provide references for clinical rational drug use. Methods Literatures about Mailuoning injection-induced ADRs published between 1992 and 2015 were retrieved,and 178 ADR cases reports were analyzed statistically. Results Mailuoning injection-induced ADRs had no association with gender, and often occurred in patients between 41-65 years old, 62.92% cases occurred within 30 mins after medication ,and the ADR cases mainly manifested as systemic damage and respiratory system damage. The main clinical manifestations were dyspnea and allergic shock. There were 2 death cases,and other patients recovered after symptomatic treatment. Conclusion Mailuoning injection can induce serious adverse reactions,and some kinds of ADRs were undescribed in instructions,so we should strengthen the medication monitoring and treating ADR timely to ensure the safety of patient medication.

关 键 词：脉络宁注射液 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]