慢性肾脏病患者血清Klotho平与肾功能损害的相关性  

Correlation between the levels of serum Klotho with renal impairment in chronic kidney disease patients

作　　者：刘其锋[1] 叶建明[1] 郁丽霞[1] 封建华[1] 何敖林[2] 李莎莎[2] 

机构地区：[1]江苏大学附属昆山医院肾脏内科,江苏省苏州市215300 [2]江苏大学附属昆山医院临床实验研究中心,江苏省苏州市215300

出　　处：《实用医学杂志》2016年第6期916-919,共4页The Journal of Practical Medicine

基　　金：江苏省苏州市"科教兴卫"青年科技项目基金资助项目(编号:KJXW2014049)

摘　　要：目的：探讨慢性肾脏病（chronic kidney disease,CKD）患者血清Klotho水平与肾功能损害的相关性。方法：收集100例CKD 1~5期的住院患者及30例健康对照者,采用ELISA法检测血清Klotho水平,观察血清Klotho水平及其与肾功能损害的关系。结果：对照组血清Klotho水平9.81（7.45,12.2）ng/m L,CKD患者血清Klotho水平2.97（1.75,5.23）ng/m L,两组比较差异有统计学意义（P〈0.01）;随着肾功能进展,Klotho水平逐渐降低（P〈0.01）;Pearson相关分析显示,CKD患者血清logKlotho水平与肾小球滤过率（e GFR）、血钙、血红蛋白呈正相关,与年龄、log肌酐、logFGF-23以及血磷呈负相关。多元回归分析显示,年龄、logScr、logFGF-23水平是影响血清logKlotho水平的独立危险因素。结论：CKD患者血清Klotho水平随肾功能下降而降低,有望成为CKD患者病情进展的预测指标。Objective To explore the relationship between the level of serum Klotho with renal impairment in chronic kidney disease（CKD） patients. Methods 100 patients with CKD 1-5 stages（CKD group） and 30 non-CKD patients（control group） were enrolled. The serum of Klotho was detected by ELISA（enzyme-linked immunosorbent assay） to investigate the correlation between the level of serum Klotho to progression of CKD. Results The levels of serum Klotho in CKD group 9.81（7.45,12.2） ng / m L and control group 2.97（1.75,5.23） ng / m L were significantly different（P〈0.01）; The Klotho level declined as renal insufficiency progressed. Pearson correlation analysis showed that serum Klotho in CKD patients was positively correlated with e GFR（estimated glomerular filtration rate）, blood calcium and hemoglobin,while was negatively correlated with phosphate, age, log_（serum creatinine）, and log_（FGF-23）. Multiple regression analysis showed age, log_（Scrand） log_（FGF-23） were independent factors for expression of serum Klotho in CKD patients. Conclusion Serum Klotho level in CKD patients decreased with the deterioration in renal function and serum Klotho maybe one of indicators to predict the progression of renal function in CKD patients.

关 键 词：慢性肾脏病 KLOTHO 肾功能损害 

分 类 号：R692[医药卫生—泌尿科学]