二甲双胍联合阿卡波糖治疗2型糖尿病的效果观察  

Efficacy of metformin combined with acarbose in treating type 2 diabetes patients

作　　者：张波庆 江淼[1] 余颖[1] 

机构地区：[1]常山县人民医院内分泌科,浙江常山324200

出　　处：《中国生化药物杂志》2016年第2期116-118,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医药卫生一般研究计划(2015KYB304)

摘　　要：目的 观察二甲双胍联合阿卡波糖治疗2型糖尿病的临床效果。方法 选取常山县人民医院内分泌科2011年3月~2015年3月期间收治的确诊为2型糖尿病的患者共70例,按随机数字表法分为观察组和对照组各35例,对照组给予二甲双胍治疗,观察组患者在对照组的基础上给予阿卡波糖治疗,随访并记录2组患者空腹血糖（fasting plasma glucose,FPG）、餐后2 h血糖（2 h postprandia glucose,2h PG）、体重指数（body mass index,BMI）、甘油三酯（triglyceride,TG）、血清总胆固醇（total cholesterol,TC）和疗效情况并比较。结果 治疗后观察组患者FPG、2h PG指标均低于对照组（P〈0.05）。治疗后观察组患者TG、TC指标均低于对照组（P〈0.05）。治疗后观察组患者BMI指标低于对照组（P〈0.05）。结论 二甲双胍联合阿卡波糖治疗2型糖尿病的效果良好,优于单独运用二甲双胍治疗。Objective To observe the effect of mefformin combined with acarbose in treatment of patients with type 2 diabetes. Methods 70 cases diagnosed with type 2 diabetes from March 2011 to March 2015 were randomly divided into the observation group and control group randomly, 35 cases in each group. The control group received metformin treatment, and observation group received acarbose on the basis of control group. The patients were followed up, the fasting plasma glucose （FPG）, 2 h postprandia glucose （2hPG）, body mass index （BMI）, triglyceride （TG）, total cholesterol （TC） and the efficacy were compared between two groups. Results After treatment, the FPG and 2hPG in observation group were lower than control group （P 〈 0. 05 ）, the TG and TC in observation group were lower than control group（ P 〈 0. 05 ）, the BMI value in observation group was lower than control group （P 〈 0. 05 ）. Conclusion The effect of mefformin combined with acarbose in the treatment of patients with type 2 diabetes is better than metformin alone.

关 键 词：二甲双胍 阿卡波糖 2型糖尿病 联合用药 

分 类 号：R587.1[医药卫生—内分泌]