黄芪多糖对冠心病患者血清TNF-α、IL-6、P-选择素、VCAM-1以及VEGF水平的影响  

Effect of astragalus polysaccharides on TNF-α,IL-6,P- selection,VCAM-1 and VEGF in patients with coronary heart disease

作　　者：张蕴颖[1] 鲍黎明[1] 

机构地区：[1]浙江省丽水市中心医院急诊科,浙江丽水323000

出　　处：《中国生化药物杂志》2016年第2期142-144,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医学会临床科研基金项目(2013ZYC-1310)

摘　　要：目的探讨黄芪多糖对冠心病患者血清肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、P-选择素(P-selectin)、血管细胞粘附因子(vascular cell adhesion molecule-1,VCAM-1)、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)水平的影响。方法收集60例冠心病患者,随机分为对照组和实验组,每组各30例,对照组给予常规治疗,实验组在常规治疗基础上给予黄芪多糖治疗,治疗14 d后,对所有患者的血清炎症因子、P-选择素、VCAM-1以及VEGF水平进行检测。结果治疗后,与对照组比较,实验组患者血清IL-6、TNF-α水平较低(均P<0.05);实验组患者的血清P-selectin、VCAM-1以及VEGF较低(均P<0.05)。结论黄芪多糖能够明显降低冠心病患者血清IL-6、TNF-α、P-selectin、VCAM-1以及VEGF水平。Objective To analysis the effect of effect of astragalus polysaccharides on serum TNF-ct, IL-6, P- selection, VCAM-1 and VEGF in patients with coronary heart disease. Methods 60 patients who were diagnosed with coronary heart disease were randomly divided into experimental group and control group, 30 cases in each group. The control group was treated with conventional therapy, and the experimental group was treated with astragalus polysaccharides on the basis of conventional therapy, after 14 d of treatment, the serum levels of inflammatory factors, P-selection, VCAM-1 and VEGF were detected in all patients. Results After treatment, compared with control group, the serum IL-6 and TNF-α levels were lower in the experimental group （all P〈 0.05 ）; the serum P-selection, VCAM-1, VEGF level were lower in the experimental group （all P〈 0.05 ）. Conclusion Astragalus polysaccharides can reduce significantly serum IL-6, TNF-α, P- selection, VCAM-1 and VEGF levels in patients with coronary heart disease.

关 键 词：黄芪多糖 冠心病 炎症因子 P-选择素 VCAM-1 VEGF 

分 类 号：R259[医药卫生—中西医结合]