大鼠颅骨骨缺损模型的影像学分析  

Imaging analysis of calvarial defect model in rats

作　　者：王晓波[1] 郑欣[2] 陈一心[2] 李东亚[2] 谢小肖 邱旭升[2] 王骏飞[2] 施鸿飞[2] 

机构地区：[1]东南大学鼓楼临床医学骨科,江苏省210008 [2]南京大学附属鼓楼医院骨科

出　　处：《江苏医药》2016年第6期628-630,共3页Jiangsu Medical Journal

基　　金：江苏省社会发展基金(BE2011604);江苏省六大人才高峰项目(2012-WS-092);南京市卫生局项目(ZKX12026;YKK13079);江苏省普通高校研究生科研创新计划资助项目(SJZZ_0030)

摘　　要：目的探讨大鼠颅骨骨缺损模型的理想缺损尺寸。方法 48只SD大鼠建立颅骨骨缺损模型,缺损直径分别为5mm(A组,16只)、6mm(B组,16只)和8mm(C组,16只)。术后行CT扫描检查,测量骨缺损的直径和面积,观察骨缺损修复情况。结果随着术后观察时间的延长,A组和B组骨缺损直径逐渐减少,断端桥接,而C组骨缺损直径无明显变化。与术后当天相比,A组和B组术后12周的骨缺损面积减少[(5.16±0.75)mm^2 vs.(20.10±0.37)mm^2和(15.55±0.29)mm^2 vs.(28.23±0.44)mm^2](P<0.05),而C组无统计学差异[(50.64±0.37)mm^2 vs.(51.27±0.37)mm^2](P>0.05)。结论大鼠颅骨骨缺损模型的最佳缺损直径是8mm。Objective To investigate the ideal size of calvarial defect in rat models.Methods The calvarial defect model was established in 48 SD rats and then equally divided into three groups of A（defect diameter of 5 mm）,B（defect diameter of 6 mm）and C（defect diameter of 8 mm）.The diameter and area of bone defect were measured by CT scanning after operation for observing bone regeneration.Results The diameters of bone defect were gradually decreased and the broken ends of fractured bone were bridged as the time went on in groups of A and B,which were not obviously changed in group C.Compared with the postoperative day,the areas of bone defect were decreased in the 12 th week after operation in groups of A and B[（5.16±0.75）mm^2 vs.（20.10±0.37）mm^2 and（15.55±0.29）mm^2 vs.（28.23±0.44）mm^2]（P〈0.05）,which was not statistically different in group C[（50.64±0.37）mm^2 vs.（51.27±0.37）mm^2]（P〈0.05）.Conclusion As the rat model with calvarial defect,a 8mm defect in diameter may be optimal.

关 键 词：颅骨缺损 动物模型 

分 类 号：R683[医药卫生—骨科学]