An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines  

环境友好碱有机催化一锅法区域选择性合成新型3,6-二芳基-4-甲基哒嗪（英文）

作　　者：Mehdi Rimaz Farkhondeh Aali 

机构地区：[1]帕亚莫.努尔大学化学系

出　　处：《Chinese Journal of Catalysis》2016年第4期517-525,共9页催化学报（英文）

基　　金：supported by the Research Council of Payame Noor University

摘　　要：This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.报道了一种新型三组分反应策略用于区域选择性合成一系列三取代的哒嗪,即于水中进行DABCO催化的苯丙酮、芳香乙二醛一水合物和水合肼三组分缩合反应.该法提供了一种绿色便利的一锅法制备各种芳基取代的3,6-二芳基-4-甲基哒嗪,它以水为溶剂,DABCO为绿色碱有机催化剂,具有高区域选择性、操作简便。

关 键 词：1 4-Diazabicyclo[2.2.2]octane （DABCO） PROPIOPHENONE Arylglyoxalmonohydrate PYRIDAZINE 

分 类 号：O621.251[理学—有机化学]