太极拳对原发性Ⅰ级高血压患者24小时动态血压和血管内皮功能的影响  

Effects of Taijiquan on 24-hour Dynamic Blood Pressure and Vascular Function in Patients with Primary Mild Hypertension

作　　者：金昊雷 庞佳佳 

机构地区：[1]上海市宝山区杨行镇社区卫生服务中心,上海201901

出　　处：《中国运动医学杂志》2016年第3期224-227,共4页Chinese Journal of Sports Medicine

基　　金：上海市宝山区科技创新专项资金(11-E-47)

摘　　要：目的:评价太极拳对原发性Ⅰ级高血压患者24h动态血压和血管内皮功能的影响。方法:选取符合入选条件的54例原发性Ⅰ级高血压患者,经过5天洗脱期后随机分为实验组和对照组,实验组每天进行太极拳运动40 min,对照组给予氨氯地平2.5 mg/d,连续干预6周。分别记录实验前一天和实验结束后一天患者的24 h动态血压(DBP),同时检测血清内皮素(endothelin,ET)和一氧化氮(nitric oxide,NO)含量。结果:实验前一天,实验组患者24 h收缩压(SBP)和24h舒张压(DBP)分别为152.44±16.21、92.92±14.35 mm Hg,对照组的患者24h SBP和24 h DBP分别为150.24±11.36、97.19±9.35 mm Hg,两组24h SBP和24h DBP水平组间比较无统计学差异(P>0.05);实验组和对照组患者血清NO浓度分别为54.72±17.23、50.24±15.52 pg/ml、ET水平分别为109.51±39.06、122.64±37.60 pg/ml,两项指标组间比较均无统计学差异(P>0.05)。实验组进行太极拳运动6周后,患者24h SBP和DBP均较治疗前均明显下降,血清ET水平下降、NO浓度明显升高,差异均具有性统计学意义(P<0.05);对照组给予氨氯地平治疗6周后,患者24h SBP和DBP均较治疗前均明显下降,差异具有统计学意义,但血清ET、NO含量与治疗前相比差异没有统计学意义(P>0.05)。结论:短期太极拳运动可以有效控制轻度高血压患者24h动态血压水平,调节血清ET/NO水平进而发挥对血管内皮功能的保护作用。Objective To observe the effects of Taijiquan on 24-hour dynamic blood pressure（DBP）and vascular function in patients with primary hypertension. Methods 54 patients with primary mild hypertension were randomly divided into experimental group and control group after 5-day wash-out period. Patients in experimental group took part in Taijiquan practice 40 minutes per day for 6 weeks. Patients in control group only took 2.5 mg of amlodipine per day for 6 weeks. 24-hour DBP and plasma ET/NO levels of all subjects were measured 1 day before and 6 weeks after the experiment. Results There was no statistical difference in24-hour DBP and plasma ET/NO levels between experimental group and control group before the experiment.24-hour DBP and plasma ET level decreased and NO level increased significantly in experimental group after6-week Taijiquan practice（P〈0.05）. 24-hour DBP decreased significantly（P〈0.05）,while the ET and NO levels remained unchanged（P〉0.05）in control group after 6-week amlodipine therapy. Conclusion Short-term Taijiquan practice could control 24-hour dynamic blood pressure effectively,and protect the vascular function via regulating plasma ET/NO concentration.

关 键 词：太极拳 原发性Ⅰ级高血压 动态血压 ET/NO 血管内皮功能 

分 类 号：R259[医药卫生—中西医结合] R247.4[医药卫生—中医内科学]