中老年2型糖尿病患者血清骨硬化蛋白和体脂肪率与骨骼的相关性  

Correlation of serum sclerostin and fat mass percentage with bone in middle-aged and elderly patients with type 2 diabetes mellitus

作　　者：景春贝 汪艳芳[2] 赵志刚[2] 郑瑞芝[2] 袁倩[2] 王丽敏[2] 任琢琢[2] 

机构地区：[1]新乡医学院,河南新乡453000 [2]郑州大学人民医院河南省人民医院内分泌科,郑州450003

出　　处：《中华实用诊断与治疗杂志》2016年第4期378-380,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省科技厅攻关项目(132102310466)

摘　　要：目的探讨中老年2型糖尿病(type 2diabetes mellitus,T2DM)患者血清骨硬化蛋白(sclerostin,SOST)、体脂肪率(fat mass percentage,FM%)的变化以及其与骨骼健康的相关性。方法病程>5a的中老年T2DM患者128例为T2DM组,同期体检健康者64例为对照组。采用ELISA测定血清SOST水平,双能X线骨密度测量L_(1-4)、左侧股骨骨密度(bone mineral density,BMD)及相应部位FM%,分析SOST、FM%、BMD等相关性。结果T2DM组血清SOST[(224.92±76.94)ng/L]、股骨FM%[(23.79±5.98)%]高于对照组[SOST(193.37±61.91)ng/L、股骨FM%(21.98±5.06)%](P<0.05),腰椎及股骨BMD[(1.11±0.16)、(0.98±0.15)cm^2/g]与对照组[(1.09±0.18)、(0.98±0.19)cm^2/g]比较差异无统计学意义(P>0.05);相关性分析显示,T2DM组血清SOST与甲状旁腺激素呈负相关(r=-0.300,P=0.010),与腰椎、股骨BMD无相关性(r=-0.160,P=0.880;r=-0.150,P=0.190);腰椎、股骨FM%与血清SOST值均呈正相关(r=0.320,P=0.004;r=0.270,P=0.015);股骨FM%与BMD明显负相关(r=-0.280,P=0.001)。结论中老年T2DM患者血清SOST水平、FM%明显增高,有可能参与了骨质疏松的病理过程。Objective To observe the changes of serum sclerostin level and the fat mass percentage（FM%）and their correlation with bone in middle-aged and elderly patients with type 2 diabetes mellitus（T2DM）.Methods Serum sclerostin was detected by ELISA in 128T2DM patients with disease course over 5 years（T2DM group）and 64 healthy volunteers（control group）.The dual energy X-ray absorptiometry was adopted to determine the bone mineral density（BMD）in lumbar（L_（1-4））and left femoral,and the FM%in the corresponding part.The correlations of serum sclerostin,FM% and BMD were analyzed.Results Serum sclerostin（（224.92±76.94）ng/L）and femoral FM%（（23.79±5.98）%）in T2DM group were significantly higher than those in control group（（193.37±61.91）ng/L,（21.98±5.06）%）（P〈0.05）.There were no significant differences in the lumbar and femoral BMD values between T2DM group（（1.11±0.16）,（0.98±0.15）cm^2/g）and control group（（1.09±0.18）,（0.98±0.19）cm^2/g）（P〉0.05）.Correlation analysis showed serum sclerostin was negatively correlated with parathyroid hormone（r=-0.300,P=0.010）and was not correlated with lumbar and femoral BMD（r=-0.160,P=0.880;r=-0.150,P=0.190）,lumbar and femoral FM% values were positively correlated with sclerostin（r=0.320,P=0.004;r=0.270,P=0.015）,and femoral FM% was negatively correlated with BMD（r=-0.280,P=0.001）in T2DM group.Conclusion The level of serum sclerostin and FM%raise in middle-aged and elderly T2DM patients,which is involved in the pathologic process of osteoporosis.

关 键 词：2型糖尿病 中老年 骨硬化蛋白 骨密度 体脂肪率 

分 类 号：R587.1[医药卫生—内分泌]