高通量血液透析与血液透析滤过在尿毒症患者中的应用效果比较  

The comparison of the clinical effect between high-flux hemodialysis and hemodiafiltration in the treatment of uremia

作　　者：雷鸣[1] 张虹[1] 

机构地区：[1]广州军区广州总医院肾脏内科,广东510010

出　　处：《中国临床新医学》2016年第3期208-210,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的比较高通量血液透析与血液透析滤过在尿毒症患者中的应用效果。方法回顾性分析2013-02～2014-08期间接受治疗的48例尿毒症患者的临床资料。随机分为观察组和对照组各24例。观察组采用高通量血液透析治疗,对照组采用常规血液透析治疗,治疗周期为80 d。检测所有患者治疗前后肌酐、血清瘦素和尿素氮指标,并与同期20名健康人的血清瘦素进行对比。结果治疗前,对照组与观察组血肌酐、血清瘦素和尿素氮差异无统计学意义。治疗后,观察组的肌酐、血清瘦素和尿素氮指标明显下降（P〈0.05）;对照组只有肌酐和尿素氮指标显著降低（P〈0.05）。结论尿毒症患者的血清瘦素指标明显高于普通健康人群。高通量血液透析治疗可以有效降低患者体内的血清瘦素、血肌酐和尿素氮水平,能达到血液透析滤过的效果,值得临床推广。Objective To investigate the efficacy of high-flux hemodialysis （HFHD） and hemodiafiltration （HDF） in the treatment of uremia. Methods A retrospective analysis of 48 cases with uremia during February 2013 to August 2014： was eonducted. The patients were randomly divided into two groups. The observation group（ n = 24） was treated with HPD and the control group （ n = 24） was treated with HDF for 80 days. Creatinine, urea nitrogen and serum leptin were tested before and after tile treatment, and the levels of serum leptin in both of the two groups were comPared with that in 20 healthy people. Results There were no significant differences in the levels of creatinine, u- rea nitrogen and serum leptin between the control group and the observation group before the treatment. After the treatment, the levels of creatinine and urea nitrogen were significantly decreased in both of the observation group and the control group （P 〈 0. 05 ） ; but the level of serum leptin only decreased in the observation group （P 〈 0.05 ）. Con- cluslon The level of serum leptin is significantly higher in the uremic patients than that in the healthy people. HF- HD can effeeti~,ely reduce the levels of serum leptin, creatinine and urea nitrogen in patients with uremia.

关 键 词：高通量 血液透析 尿毒症 应用效果 

分 类 号：R692[医药卫生—泌尿科学]