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作 者:王晓丽[1] 王兆亚 郭晓强[1] 张奕华[2] 尹健[1]
机构地区:[1]江南大学生物工程学院糖化学与生物技术教育部重点实验室,江苏无锡214122 [2]中国药科大学药物科学研究院,江苏南京210009
出 处:《药学学报》2016年第4期507-516,共10页Acta Pharmaceutica Sinica
基 金:江苏省自然科学基金资助项目(BK20140154);江南大学自主科研计划青年基金资助项目(JUSRP11428)
摘 要:硫化氢(H_2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第三种内源性气体信号分子,在机体中发挥着重要的生物学效应。研究表明,H_2S参与了心血管系统和神经系统的病理生理过程,并与多种疾病的发生和发展密切相关。本文对近年来H_2S的生物学特性、生理作用、H_2S供体及其相关药物的研究进展做一综述,为相关新药的研发与临床治疗提供有价值的参考。Hydrogen sulfide(H_2S) is considered as a new member of gasotransmitter family, following nitric oxide(NO) and carbon monoxide(CO). H_2S exerts important biological effects in mammals, which has drawn more and more attention in recent years. It is proved that H_2S has a role in the regulation of physiological and pathophysiological processes in the cardiovascular system and the nervous system. Several cardiovascular and nervous diseases are connected to H_2S. H_2S-releasing agents(also known as H_2S donors) have been widely used not only as useful research tools but also potential therapeutic agents. In this review, we provide an overview of the chemistry and biology of H_2S, and summarize the chemistry and biological activity of some natural and synthetic H_2S donors. We introduce the developments of currently available H_2S-releasing drugs including H_2S-non-steroidal anti-inflammatory drugs, H_2S-nervous system drugs and NO-H_2S-releasing drugs. We hope this review will be a value reference in the development of H_2S-releasing drugs in the treatment of cardiovascular and nervous diseases.
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