钩藤在阿尔茨海默病模型中的药理作用研究进展  

Research progress in pharmacological effects of Uncaria Hook on Alzheimer disease models

作　　者：刘林[1] 赵宇红[2] 曾常青[1] 曾宇[1] 

机构地区：[1]广东药科大学中药学院,广东广州510006 [2]广东药科大学药科学院,广东广州510006

出　　处：《药学学报》2016年第4期536-542,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金青年科学基金资助项目(81403129);贵州省剑河县中药材产业科技合作专项计划项目(剑科合字(2014)4号)

摘　　要：阿尔茨海默病(Alzheimer disease,AD)是发病率最高的一种神经退行性疾病,为老年期痴呆主要的类型,随着人均寿命延长,AD发病率越来越高,严重威胁老年人的生活质量。AD病因和病理机制尚不明确,存在tau蛋白异常磷酸化、β-淀粉样蛋白(amyloid-beta protein,Aβ)毒性损伤、基因突变、胆碱能神经系统受损、神经炎症和氧化应激等多种假说。基于各种假说,钩藤在AD模型中已有大量研究。本文结合AD相关病理机制对近年来钩藤在AD模型方面的相关研究进行综述,为进一步开发钩藤药用潜能提供参考资料。The most common neurodegenerative disease, Alzheimer disease（AD） constitutes the majority of all senile dementia cases. Extending life expectancy contributes to the increased incidence of AD, which is a serious threat to the quality of life of the elderly. The etiology and pathogenesis of AD are not absolutely clear. There are various kinds of hypotheses, such as abnormal phosphorylation of tau proteins, amyloid-beta protein toxicity, gene mutation, degeneration of cholinergic system, neuroinflammation, oxidative stress. Based on the above-mentioned theories, lots of studies of Uncaria Hook have been conducted in Alzheimer disease models. In this paper, we reviewed the latest research of Uncaria Hook on Alzheimer disease models to provide reference for further development of Uncaria Hook＇s medicinal potential.

关 键 词：钩藤 阿尔茨海默病 谷氨酸 炎症 Β-淀粉样蛋白 乙酰胆碱 TAU蛋白 氧化应激 

分 类 号：R965[医药卫生—药理学]