儿茶酚氧位甲基转移酶与疾病的关系  

The relationship between catechol O-methyltransferase and diseases

作　　者：钱星凯[1,2] 夏杨柳[1] 窦同意 侯洁[2] 马红[2] 葛广波[1] 杨凌[1] 秘晓林[2] 

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023 [2]大连医科大学,辽宁大连116044

出　　处：《药学学报》2016年第4期543-551,共9页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2013CB531800);新药创制重大专项(2012ZX09501001;2012ZX09506001);辽宁省教育厅科研项目(L2013345);辽宁省科技厅自然科学基金资助项目(2013023049)

摘　　要：儿茶酚氧位甲基转移酶(COMT)是内源基因表达的二相代谢酶,由22号染色体表达。主要将S-腺苷甲硫氨酸上的甲基转移至底物的羟基上,使底物的一个羟基甲基化。COMT在体内的主要作用是代谢儿茶酚类的化合物,例如:多巴胺、肾上腺素、去甲肾上腺素、雌二醇等化合物,此外还能代谢体外通过饮食及药物摄入的儿茶酚类化合物。由于COMT在体内与化合物的代谢密切相关,COMT代谢失常能够引起很多疾病或者罹患疾病的风险增加,例如:帕金森病、精神分裂症、乳腺癌等疾病。本综述通过阐述COMT代谢紊乱引起的疾病尝试说明COMT与其相关疾病之间的联系,旨在能够对COMT代谢相关疾病提供有效的治疗方法。Catechol O-methyltransferase（COMT）, one of the endogenous phase II metabolizing enzymes, expressed by chromosome 22. COMT catalyzes the transfer of a methyl group from common methyl donor S-adenosyl-L-methionine（Ado Met or SAM） to one of the catechol hydroxyls. COMT participates in the metabolism of many catechols in vivo, e.g. dopamine, epinephrine, noradrenaline, estradiol. Furthermore COMT also plays important roles in the metabolism of xenobiotic catechols from food and drug. COMT play a critical role in the management of catechols. Metabolism disorders of COMT can cause many diseases or an increased risk of diseases, e.g. Pakinson diseases, schizophrenia, and breast cancer. In this review, we explains the relationship of COMT and related-diseases through expounding disease caused by the COMT metabolic disorders. Finally, we hope that there will be more effective treatments for the COMT metabolism related diseases.

关 键 词：儿茶酚氧位甲基转移酶 代谢 疾病 

分 类 号：R963[医药卫生—微生物与生化药学]