冠心病患者血浆microRNA155和TNF-α变化水平及相关性研究  

Correlation and the Changes Between Plasma microRNA155and TNF-α in Patients with CHD

作　　者：黄珊[1] 李天发[1] 王军[1] 杨洋[1] 左琦[1] 

机构地区：[1]海南医学院附属医院心内科,海南海口570102

出　　处：《医学临床研究》2016年第3期454-457,共4页Journal of Clinical Research

基　　金：海南医学院科研培育基金（HY2012-001）

摘　　要：【目的】探讨冠心病（CHD）患者血浆miRNA155、肿瘤坏死因子α（TNF-α）变化水平及相关性研究。【方法】选择2013年12月至2014年6月本院收治的75例CHD患者。将其分为两组，急性冠状动脉综合征（ACS）组（39例）和慢性心肌缺血综合征（CIS）组（36例）；同时选择同期来本院健康体检者34例作为对照组。对比分析三者基础资料、血浆TNF—α、microRNA155变化，以及ACS组和CIS组血浆miRNA155与TNF-α相关性。【结果】ACS组TNF—α、miRNA155水平显著高于CIS组和对照组，CIS组TNF—α、miRNA155水平显著高于对照组，差异均具有统计学意义（均P〈0．05）。血浆miRNA155与TNF-α呈显著正相关（r=0．784，P〈0．05）。【结论】CHD患者血浆miRNA155、TNF-α水平显著升高，血浆miRNAα55和TNF—α水平呈显著正相关性。[Objective]To explore the correlation and the changes between plasma micro RNA155 and TNF-α of coronary artery disease patients. [Methods]Seventy-five cases of patients with coronary artery disease who were diagnosed from December 2013 to June 2014, were selected and divided into acute coronary syndrome（ACS, n =39） and chronic ischemic syndrome （CIS, n =36） and at the same time 34 cases of healthy people who underwent health exam were chosen as the control group. Comparison and analysis of the basic data, the changes in plasma TNF-α level and microRNA155, and the correlation between plasma miRNA155 and TNF-α in ACS group and CIS group were performed.[Results] The levels of TNF-α in the ACS Group were significantly higher than that in the CIS group and the control group. The levels of TNF-α in the CIS group were notably higher than that in the control group, with statistical difference（both P 〈 0.05）. Plasma miR- NA155 was positively correlated with TNF-α （ r =0.784 R, P 〈0.05）. [Conclusion] The levels of plasma miRNA155 and TNF-α are significantly increased in CHD patients, and the levels of plasma miRNA155 and TNF-α are positively correlated with.

关 键 词：冠心病/血液 微RNAs/血液 肿瘤坏死因子α/血液 

分 类 号：R541.4[医药卫生—心血管疾病]