辽宁地区FoxO3a基因rs4946936多态性与2型糖尿病的相关性研究  

Association of FoxO3a Gene rs4946936 Polymorphisms with Type Ⅱ Diabetes in Liaoning Population

作　　者：邓霖[1] 王玉霞[1] 刘畅[1] 赵雨舒 赵阳[1] 

机构地区：[1]中国医科大学附属第四医院内分泌科,辽宁沈阳110032

出　　处：《医学临床研究》2016年第3期488-489,493,共3页Journal of Clinical Research

摘　　要：【目的】探讨FoxO3a基因rs4946936单核苷酸多态性与辽宁地区2型糖尿病（T2DM）相关性。【方法】收集374例T2DM患者（T2DM组）及283例非糖尿病健康人群（对照组），检测两组FoxO3a基因rs4946936单核苷酸多态性，比较两组等位基因与基因型分布频率。【结果】T2DM组中C等位基因、CC基因型频率分别为76．74％、58．82％，与对照组的C等位基因频率77．21％、CC基因型58．66％比较差异无统计学意义（P〉0．05）。【结论】FoxO3a基因rs4946936单核苷酸多态性与T2DM无相关性。[Objective]To study the association of alleles and genotype frequencies of rs4946936 single nucleotide polymorphisms in FoxO3a and their relationship with type Ⅱ diabetes mellitus in Liaoning Han population. [Methods]Application of case-control study was used to determine the distribution of alleles and genotype frequencies of rs4946936 single nucleotide polymorphisms in FoxO3a in 374 type Ⅱ diabetes mellitus subjects and 283 non-diabetes control subjects. [Results]The C allele frequencies in the case and control groups were 76.74% and 77.21 %, respectively, The CC genotype frequencies in the case and control groups were 58.82 % and 58.66%, respectively; there was no statistically significant difference between type 2 diabetes patients and non-diabetic subjects. [Conclusion]The alleles and genotype frequencies of rs4946936 single nucleotide polymorphisms in FoxO3a is not associated with type II diabetes mellitus.

关 键 词：叉头转录因子类/遗传学 多态性 单核苷酸 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]