309株铜绿假单胞菌的分布及耐药性  

Distribution and drug resistance of 309 strains of Pseudomonas aeruginosa

作　　者：张晓兰[1] 胥振阳[1] 李晓辉[1] 陈世财[1] 张芳[1] 

机构地区：[1]首都医科大学附属北京潞河医院,北京通州101149

出　　处：《中国微生态学杂志》2016年第4期440-442,共3页Chinese Journal of Microecology

摘　　要：目的分析铜绿假单胞菌的耐药特点,为临床合理选药提供依据。方法对首都医科大学附属北京潞河医院2014年1月至12月分离的铜绿假单胞菌,采用全自动细菌鉴定仪,用微量稀释法进行药敏试验,并用WHONET 5.6软件对药敏结果进行统计分析。结果 309株铜绿假单胞菌对哌拉西林、哌拉西林/他唑巴坦、阿米卡星、妥布霉素的敏感性菌大于90.0%,对头孢吡肟、庆大霉素的敏感性分别为84.8%、84.5%,对亚胺培南、美罗培南的敏感率为71.5%、74.1%,对氨曲南的耐药率达78.0%;标本来源主要来自呼吸道标本,其次为分泌物标本、尿液标本;科室主要以呼吸科、神经外科、ICU为主。结论对铜绿假单胞菌感染应优先选择哌拉西林、哌拉西林/他唑巴坦、阿米卡星、妥布霉素等,临床应限制氨曲南的使用。Objective To analyze the drug-resistance of Pseudomonas aeruginosain our hospital,and provide guidance for the clinical treatment.Methods Microdilution method was used to test the susceptibility of Pseudomonas aeruginosaisolated in our hospital in 2014 to commonly used antibiotics.The results were analyzed with WHONET 5.6software in personal computer.Results The sensitivity rates of the 309 strains to Piperacillin,Piperacillin/tazobactam,Amikacin and Tobramycin were over 90.0%,and to Cefepime,Gentamicin,Imipenem and Meropenem were 84.8%,84.5%,71.5%and 74.1%,respectively.The resistance rate to Azactam was 78.0%.The specimens were mainly derived from respiratory tract specimens,followed by secretion and urine samples,mainly from respiration department,neurosurgery department and ICU.Conclusion Piperacillin,Piperacillin/tazobactam,Amikacin and Tobramycin are still the preferred options for the treatment of Pseudomonas aeruginosa infections in our hospital,while the use of Azactam should be restricted.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]