甲苯咪唑和芬苯达唑对灵长类动物毛首线虫的驱虫效果观察  

Anthelmintic Effect of Mebendazole and Fenbendazole on Trichuris Infection in Primates

作　　者：赵波[1] 李梅[2] 王强[1] 牛李丽[1] 邓家波[1] 严慧娟[1] 杨光友[2] 

机构地区：[1]成都市动物园,成都610081 [2]四川农业大学动物医学院,成都611130

出　　处：《四川动物》2016年第2期249-251,255,共4页Sichuan Journal of Zoology

基　　金：成都大熊猫繁育研究基金项目(No.CPF2012-04)

摘　　要：使用复方甲苯咪唑片剂按10 mg·kg^(-1)×5 d、20 mg·kg^(-1)×3 d、40 mg·kg^(-1)×5 d和芬苯达唑粉剂按10 mg·kg^(-1)×3 d对感染毛首线虫Trichuris spp.的灵长类动物拌料喂服,测定用药前后每克粪样中虫卵数,计算虫卵减少率和虫卵转阴率以评估药物驱虫效果。结果表明,川金丝猴Rhinopithecus roxellana按10 mg·kg^(-1)×5 d、黑叶猴Presbytis francoisi等7种动物按20mg·kg^(-1)×3 d、短尾猴Macaca arctoides和猕猴M.mulatta按40 mg·kg^(-1)×5 d用复方甲苯咪唑片剂投药后,虫卵减少率和虫卵转阴率均能达到100%,芬苯达唑的驱虫效果较差。甲苯咪唑对灵长类动物毛首线虫的驱虫效果较好,投药方便、安全。筛选出安全、高效和使用方便的抗毛首线虫药物及驱虫程序,为灵长类动物毛首线虫病的防控提供技术支持。In order to screen efficient anthelmintic drug and procedure for trichuriasis in primates,the compound mebendazole tablets and fenbendazole in four different schemes（ group Ⅰ： mebendazole 10 mg·kg^-1× 5 d,group Ⅱ： mebendazole 20 mg·kg^-1× 3 d,group Ⅲ： mebendazole 40 mg·kg^-1× 5 d and group Ⅳ： fenbendazole 10 mg·kg^-1× 3 d）were used to treat Trichuris spp. infection in primates. The anthelmintic efficacy was evaluated by calculating the egg reduction rate and egg negative rate. The results showed that the egg reduction rate and egg negative rate were 100% when mebendazole used as 10 mg·kg^-1× 5 d for Rhinopithecus roxellana,20 mg·kg^-1× 3 d for Presbytis francoisi and 6 other primates and mebendazole 40 mg·kg^-1× 5 d for Macaca arctoides and M. mulatta. Poor anthelmintic efficacy was observed in fenbendazole treated group. This preliminary study also suggested that mebendazole was a safe and anthelmintic drug for Trichuris infection in primates.

关 键 词：灵长类动物 毛首线虫 甲苯咪唑 芬苯达唑 虫卵减少率 虫卵转阴率 

分 类 号：S855.9[农业科学—临床兽医学]