Functional spermatid-like cells derived from the ground-state embryonic stem cells in vitro  

作　　者：Yan Zhang Yixun Liu 

机构地区：[1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences

出　　处：《Science China(Life Sciences)》2016年第4期436-437,共2页中国科学（生命科学英文版）

摘　　要：Embryonic stem cells（ESCs）are pluripotent and can self-assemble to form cell clusters or embryoid bodies（EBs）,which can then differentiate into all cell types of the three germ layers,as among which one is the primordial germ cell（PGCs）（Daley,2007）.In vivo PGCs are the gamete founder cells（the ooctyes and sperms）,which transmit genetic information from one generation to the next generation to maintain mammalian life cycles.About 15%of couples in China are infertile;Embryonic stem cells(ESCs)are pluripotent and can self-assemble to form cell clusters or embryoid bodies(EBs),which can then differentiate into all cell types of the three germ layers,as among which one is the primordial germ cell(PGCs)(Daley,2007).In vivo PGCs are the gamete founder cells(the ooctyes and sperms),which transmit genetic information from one generation to the next generation to maintain mammalian life cycles.About 15%of couples in China are infertile;some of these infertility cases

关 键 词：primordial pluripotent infertility embryonic PGCs maintain transmit founder differentiate methylation 

分 类 号：Q492[生物学—生理学]