双环醇治疗儿童EB病毒感染所致肝功能损害的疗效观察  

Clinical effect of bicyclol tablet on hepatic lesions caused by Epstein-Barr virus infection in children

作　　者：滕旭[1] 许玲芬[1] 孙梅[1] 郭静[1] 

机构地区：[1]中国医科大学附属盛京医院小儿消化科,沈阳110004

出　　处：《中国小儿急救医学》2016年第3期182-185,共4页Chinese Pediatric Emergency Medicine

基　　金：国家自然科学基金青年基金资助项目（81400585）;辽宁省科委基金资助项目（2014021042）

摘　　要：【摘要】目的评估双环醇片治疗EB病毒感染所致儿童肝功能损害的疗效和安全性。方法采用单中心回顾性对照临床研究，对121例EB病毒感染肝炎患儿进行回顾性分析，按照治疗时应用的保肝药物不同分成双环醇组（63例）和复方甘草酸苷组（58例），分别用双环醇片（百赛诺）和复方甘草酸苷治疗，两组疗程均为8周。观察治疗前EB病毒载量，治疗前及治疗后1周、4周、8周血常规、尿常规、ALT、AST，同时观察一般状况及相关症状、体征。结果（1）双环醇组患儿ALT水平较复方甘草酸苷组患儿降低更为显著，且治疗8周疗效优于治疗1周和4周（P〈0．01）；（2）治疗8周后双环醇组的转氨酶恢复情况较复方甘草酸苷组更为显著（P〈0．05）；（3）两组患儿用药过程中均未出现明显不良反应。结论双环醇片对儿童EB病毒感染肝炎患者有良好的疗效和安全性。Objective To evaluate the efficacy and safety of bicyclol tablet on hepatic lesions caused by Epstein-Barr virus （EBV） infection in children. Methods A single-center controlled retrospective study was conducted in 121 children with hepatic lesions caused by EBV infection for evaluating safety ,tolerability, and efficacy of treatment with bicyclol tablets or Glycyrrhizin capsules. Children in bicyclol group （ n = 63 ） were treated with bicyclol tablets and control group （ n = 58 ） were treated with Glycyrrhizin capsules. The course of the treatment were both 8 weeeks for two groups. The level of the EBV load pretreatment and plas- ma aminotransferase,blood routine, urine routine pretreatment and 1 week,4 weeks and 8 weeks after treat- ment were analyzed retrospectively. Results （ 1 ） The plasma ALT level significantly decreased in the bicy- clol group compared with that in the control group （P 〈 0. 01 ）, especially the level after 8 weeks treatment. （2） Bicyclol was more effective in the bicyclol group than Glycyrrhizin capsules in the control group （ P 〈 0. 01 ）. （3） Both groups had no significantly adverse events. Conclusion Bicyclol tablet can decrease plas- ma aminotransferase level, especially ALT, in children caused by EBV infection with better efficiency and safety.

关 键 词：儿童 肝炎 EB病毒 双环醇 

分 类 号：R725.1[医药卫生—儿科]