辅酶Q的生物合成及其最新进展  

The Biosynthesis of Coenzyme Q and its Recent Progress

作　　者：崔铁忠[1] 卢康荣[2] 李银霞[3] 王万山[4] 

机构地区：[1]耶鲁大学医学院细胞生物学系,美国纽黑文06520 [2]南方医科大学基础医学院,广东广州510515 [3]犹他大学医学院肿瘤科学系,美国盐湖城84112 [4]南方医科大学比较医学研究所,广东广州510515

出　　处：《科技视界》2016年第10期25-27,共3页Science & Technology Vision

基　　金：广东省科技计划项目(2011B060300028;2012B040304010)

摘　　要：辅酶Q是线粒体电子传递链的重要组成成分,它介导电子从复合物I和复合物II传递到复合物III。近年来,随着研究的不断深入,辅酶Q在其他方面的功能逐渐被发现,促进了其作为药品和保健品的广泛应用。对于辅酶Q的生物合成途径,从低等到高等真核生物都是高度保守的,以在简单真核生物酵母中的研究尤为清晰。辅酶Q的生物合成包含多个步骤,多数参与基因已被发现,但有些基因功能还未知。本文综述了近年来辅酶Q生物合成的最新进展,以期为后续研究提供帮助。Coenzyme Q is a well-known component of the electron transport chain. It transfers electrons from NADH-and succinate-dehydrogenase to cytochrome reductase. In the recent years, increasing amounts of studies discovered multiple functional roles of coenzyme Q and led to its wide use in medicine and food supplements. The biosynthetic pathway of coenzyme Q is highly conserved from yeast to man, and is well-studied in yeast systems.The pathway includes multiple steps and the majority of genes has already been elucidated. This review will focus on the recent progress of biosynthetic pathway and I hope to guide the future coenzyme Q research.

关 键 词：辅酶Q 线粒体 抗氧化剂 电子传递链 

分 类 号：Q946.88[生物学—植物学]