HBV父婴垂直传播的研究进展  

Research advances in paternal- fetal vertical transmission during HBV infection

作　　者：张凯[1] 蔺淑梅[1] 杨雪亮[1] 孔颖[1] 刘小静[1] 张曦[1] 石磊[1] 陈云茹[1] 叶峰[1] 李娜 

机构地区：[1]西安交通大学第一附属医院,西安710061 [2]陕西省妇幼保健院,西安710003

出　　处：《临床肝胆病杂志》2016年第3期579-583,共5页Journal of Clinical Hepatology

摘　　要：HBV感染是一个严重威胁人类健康的全球性公共卫生问题。父婴垂直传播(P-FT)是HBV持续感染的主要来源之一,其传播率与母婴垂直传播相当,近几年受到越来越多的关注,成为一个国内外研究的热点。P-FT通过精子途径传播已得到证实,但相关机制尚未阐明。研究显示父方血清、精液HBV DNA高载量及血清HBe Ag阳性是P-FT发生的主要危险因素。HBV DNA一旦随机整合入精子后可影响精子质量,引起男性不育,甚至可能影响母亲妊娠结局。目前孕前干预是阻断P-FT的最主要措施,包括父亲抗病毒治疗及母亲主动免疫。Hepatitis B virus（ HBV） infection is a global public health problem which greatly threatens human health. Paternal- fetal vertical transmission（ P- FT） is one of the leading causes of persistent HBV infection,and has a transmission rate similar to that of mother- to- child vertical transmission. In recent years,P- FT has been attracting more and more attention and has become a hot research topic at home and abroad. It has been confirmed that P- FT occurs via sperm,but the mechanism remains unknown. Studies have shown that a high HBV DNA load in serum and semen and positive serum HBe Ag are the major risk factors for the occurrence of P- FT. Random integration of HBV DNA into sperm can affect sperm quality,cause male infertility,and even affect the maternal pregnancy outcome. Currently the most important measure to block P- FT is pre- pregnancy intervention,including antiviral therapy for the father and active immunization for the mother.

关 键 词：肝炎 乙型 肝炎病毒 乙型 疾病传播 垂直 综述 

分 类 号：R512.62[医药卫生—内科学]