2型糖尿病肾病患者尿足细胞标志蛋白和血管内皮生长因子水平与氧化应激的相关性  

Association of urinary podocalyxin and vascular endothelial growth factor levels with oxidative stress in patients with type 2 diabetes nephropathy

作　　者：董闪闪[1] 张洁[1] 刘璠[1] 秘玉静[2] 李欣盼 周慧敏[1] 

机构地区：[1]河北医科大学第一医院内分泌科 [2]河北医科大学第一医院检验科

出　　处：《重庆医学》2016年第10期1334-1336,共3页Chongqing medicine

基　　金：河北省卫生厅重点科技研究计划(20130260)

摘　　要：目的探讨2型糖尿病(T2DM)并发不同程度肾病患者尿足细胞标志蛋白(PCX)和血管内皮生长因子(VEGF)水平变化,及其与氧化应激的关系。方法 186例T2DM患者按照24h尿清蛋白排泄率(UAER)分为单纯T2DM组(SDM组,62例)、微量组(NA组,60例)、大量组(MA组,64例),另取24hUAER正常者作对照(NC组,60例)。分别检测PCX、VEGF、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)和丙二醛(MDA)水平。结果与其他3组比较,MA组VEGF、PCX及MDA水平最高(P<0.01),SOD和GSH-px水平最低(P<0.01,P<0.05)。VEGF、UAER、HbA1c是尿PCX的独立危险因素。结论糖尿病肾病患者尿PCX及血VEGF与氧化应激相关,氧化应激与足细胞的损伤密切相关。Objective To investigate the change of urinary podocalyxin（PCX）and vascular endothelial growth factor（VEGF）levels and its association with the oxidative stress in the patients with type 2diabetes mellitus（T2DM）complicating different degrees of diabetic nephropathy.Methods Totally 186 patients with T2 DM were divided into the pure T2DM（SDM,62cases）,trace amount group（NA group,60cases）and massive amount group（MA group,64cases）according to the 24 hurinary albumin excretion rate（UAER）.60 cases of normal 24 hUAER were taken as the control group（NC group）.The levels of PCX,VEGF,superoxide dismutase（SOD）,malondialdehyde（MDA）and glutathione peroxidase（GSH-px）were determined.Results Compared with other three groups,the level of VEGF,PCX and MDA in the MA group were highest（P〈0.01）,while the levels of SOD and GSH-px were lowest（P〈0.01,P〈0.05）.VEGF,UAER,HbA1 cwere the independent risk factors for urinary PCX.ConclusionIn patients with diabetic nephropathy,urinary PCX and VEGF are correlated with the oxidative stress,while the oxidative stress is closely correlated with glomerular podocyte injury.

关 键 词：糖尿病肾病 尿足细胞标志蛋白 血管内皮生长因子 氧化性应激 

分 类 号：R587.2[医药卫生—内分泌]