非小细胞肺癌PET/CT表现与病理特征之间的相关性分析  

Correlation between PET/CT appearance and pathological characters in Non-Small Cell Lung Cancer

作　　者：叶媛媛[1] 周丽娟[2] 郏潜新[2] 任德标 林智刚[2] 

机构地区：[1]湖北省黄冈市中心医院呼吸内科,湖北黄冈438000 [2]福建漳州解放军第175医院厦门大学附属东南医院医学影像科,福建漳州363000

出　　处：《医学影像学杂志》2016年第3期442-445,共4页Journal of Medical Imaging

摘　　要：目的探讨非小细胞肺癌PET/CT与病理特征之间的相关性。方法回顾性分析55例经病理证实的非小细胞肺癌患者的PET/CT与病理学资料,将肿瘤的PET/CT指标SUVavg、SUVmax与肿瘤的Ki-67、EGFR表达水平、MVD之间做相关分析。结果非小细胞肺癌的SUVmax与Ki-67之间呈正相关(r=0.73,P<0.05),与MVD之间呈正相关(r=0.58,P<0.05)。低分化非小细胞肺癌SUVmax值、EGFR突变率分别为10.92±2.14、69.6%,均大于高分化组(P<0.05)。结论非小细胞肺癌的PET/CT表现与肿瘤的病理学特征具有一定关联,可通过SUV值评估肿瘤的细胞增殖水平、微血管密度与EGFR突变情况。Objective To study the correlation between PET/CT appearance and pathological characters in non-small cell lung cancer （NSCLC）.Methods The PET/CT data of 55 patients with NSCLC diagnosed by pathology were retrospectively analyzed , and compared with histopathology results .Results The SUVmax was positively correlated with Ki-67（ r =0.73, P〈0.05）, and positively correlated with MVD （ r =0.58, P 〈0.05）.The SUVmax values and rates of EGFR mutation in low differentia-tion group were 10.92 ±2.14, 69.6%, and were significantly higher than those in high differentiation group （ P 〈0.05）.Con-clusion There were correlations between PET/CT appearance and pathological characters in NSCLC .It is feasible to evaluate Ki-67, MVD in vivo using the SUV value in NSCLC .

关 键 词：非小细胞肺癌 正电子发射断层显像术 细胞生长指数 微血管密度 

分 类 号：R814.42[医药卫生—影像医学与核医学] R735.2[医药卫生—放射医学]