不同功能单体制备2-氨基喹啉印迹聚合物的分子识别特性  

Molecular Recognition Properties of 2-Aminoquinoline-imprinted Polymers Synthesized Using Different Functional Monomers

作　　者：张铁莉[1] 刘征原[1] 

机构地区：[1]唐山师范学院化学系,河北唐山063000

出　　处：《化学试剂》2016年第4期353-356,共4页Chemical Reagents

基　　金：唐山师范学院资助团队支撑重点项目(2014-D07)

摘　　要：以2-氨基喹啉(2-AQ)为模板分子,分别以两种不同性质的酸性功能单体甲基丙烯酸(MAA)和三氟甲基丙烯酸(TFMAA)为功能单体,乙腈(Me CN)为致孔剂,制备了2-AQ分子印迹聚合物P(MAA)和P(TFMAA),用色谱法表征了其分子识别性能,并比较了功能单体的性质对印迹效应的影响。结果表明,P(MAA)和P(TFMAA)对2-AQ均具有显著的印迹效应,在V(HAc)∶V(Me CN)=5∶95流动相中,P(MAA)和P(TFMAA)对2-AQ的印迹因子IF分别为12.4和4.52。研究结果表明,能与2-AQ形成环状氢键的功能单体MAA和其主要形成单一氢键或静电作用的TFMAA相比较,环状氢键的形成更有利于印迹聚合物对2-AQ的选择性识别。Two molecularly imprinted polymers P（ MAA） and P（ TFMAA） were prepared by non-covalent molecular imprinting technique using 2-aminoquinoline（ 2-AQ） as the template molecule and methacrylic acid（ MAA） and trifluoromethacrylic acid（ TFMAA） with different acidity as functional monomers,respectively,in the presence of acetonitrile porogen. The molecular recognition performances were evaluated by high-performance liquid chromatography. Also the comparison was made between the molecular imprinting effect of P（ MAA） and that of P（ TFMAA） in order to reveal the role of MAA and TFMAA on molecular recognition ability of molecularly imprinted polymers. The results demonstrated that both of the imprinted polymers P（ MAA） and P（ TFMAA） showed noticeable imprinting effects for 2-AQ. And the molecular imprinting factors of P（ MAA） and P（ TFMAA） for2-AQ were 12. 4 and 4. 52,respectively,in the mobile phase of V（ HAc） ∶ V（ Me CN） = 5∶ 95. The result confirmed that MAA interacting with 2-AQ via cyclic / cooperative hydrogen bonding is more favorable for the preparation of high selective 2-AQ-binding imprinted polymer than TFMAA which interacts with 2-AQ via single hydrogen bonding or electrostatic interaction when they were chosen as the functional monomers.

关 键 词：2-氨基喹啉 分子印迹聚合物 分子识别 功能单体 高效液相色谱 

分 类 号：O631.3[理学—高分子化学]