基于Y-STR分型的中国汉族群体遗传关系  

Analysis of genetic relationship in Chinese Han populations through Y-STR genotyping

作　　者：师文远[1,2] 王瑛[1] 李海霞[1] 张楚楚[1] 李燃[1] 欧雪玲[1] 童大跃[1] 孙宏钰[1] 

机构地区：[1]中山大学中山医学院法医学系,广东广州510080 [2]厦门市公安局刑事科学技术研究所,福建厦门361003

出　　处：《热带医学杂志》2016年第3期281-284,共4页Journal of Tropical Medicine

基　　金：国家自然科学基金面上项目(81273347)

摘　　要：目的通过Y染色体短串联重复(Y-STR)分型研究中国各汉族群体的遗传学关系。方法收集整理中国汉族群体的17个Y-STR基因座等位基因频率数据,计算各群体之间的Nei's遗传距离,建立N-J系统发生树。结果云南泸西汉族与成都汉族群体之间遗传距离最大(0.126812),山西太原汉族与陕西渭南汉族群体之间遗传距离最小(0.004298)。中国汉族群体具有明显南北方差异。结论中国不同汉族群体之间存在Y-STR多态性的差异,为利用Y-STR分型进行男性汉族行为人的地域推断提供可能。Objective To investigate genetic relationships in Chinese Han populations through 17 Y chromosomal short tandem repeats（Y-STRs） genotyping. Methods Allele frequencies of 17 Y-STR loci from 18 different Chinese Han populations were collected. Then Nei＇s genetic distance among these 18 groups were calculated and phylogenetic trees were built using the Neighbor-joining method. Results The largest genetic distance was observed between Yunnan Han group and Chengdu Han group（0.126812）,while the smallest one was between Shanxi Han group and Shanxi2 Han group（0.004298）. There was significant difference between northern Han groups and southern Han groups. Conclusion There is significant differences among Chinese Han populations in terms of Y-STR polymorphisms,which makes it possible to infer male geographical origin based on Y-STR genotyping.

关 键 词：法医学 Y-STR 中国汉族 群体遗传关系 

分 类 号：Q347[生物学—遗传学]