海藻酸钠/CaCO_3医用封闭剂凝胶化时间的调控  

Tuning Gelation Time of Sodium Alginate/CaCO_3 Base Hydrogel for Using as Medical Sealants

作　　者：吴国华[1,2] 张恒 纪晓寰[1,4] 华艳萍[1,4] 孙宾[1,4] 王炜[2,5] 邢程 

机构地区：[1]东华大学纤维材料改性国家重点实验室,上海201620 [2]东华大学化学化工与生物工程学院,上海201620 [3]苏州安德佳生物科技有限公司,江苏苏州215123 [4]东华大学材料科学与工程学院,上海201620 [5]东华大学生态纺织教育部重点实验室,上海201620

出　　处：《东华大学学报（自然科学版）》2016年第1期67-72,共6页Journal of Donghua University(Natural Science)

摘　　要：采用4种典型碳酸钙(微米碳酸钙、纳米碳酸钙、轻质碳酸钙和重质碳酸钙),分别与葡萄糖酸内酯(GDL)组成钙离子释放体系,使海藻酸钠水溶液可控凝胶化,研究了碳酸钙与海藻酸钠羧酸根的摩尔比(f)、GDL与碳酸钙的摩尔比(n)和海藻酸钠质量分数(c)对海藻酸钠水凝胶的凝胶化时间及力学性能的影响.研究结果表明:在温度为37℃,f值为0.8、n值为1.4、c值为2.0%时,轻质碳酸钙体系的凝胶化时间为2.5min,且形成凝胶的抗压强度为0.145 MPa,因而该凝胶具备一定的力学性能,可作为医用封闭剂的基体.Calcium carbonate（CaCO_3）and gluconolactone（GDL）were composed together as calcium ion slow-release system.Four typical kinds of CaCO_3（micron-CaCO_3,nano-CaCO_3,light CaCO_3 and ground CaCO_3）were used as calcium source for making the gelation of sodium alginate controllable.The effects of different parameters（including the molar ratio of CaCO_3 and carboxyl group（f）,the molar ratio of GDL and CaCO_3（n）,the mass fraction of sodium alginate solution（c））on hydrogels＇gelation time and mechanical properties were studied.The results show that the gelation time of light CaCO_3 system is about 2.5 min under the condition of 37℃,f valued0.8,nvalued1.4 and c valued2.0%,the compressive strength of the hydrogels is 0.145 MPa,they also have certain mechanical properties and can be used as the substrate of the medical sealants.

关 键 词：海藻酸钠 碳酸钙 凝胶化时间 力学性能 医用封闭剂 

分 类 号：R318.08[医药卫生—生物医学工程]