甲基壬乙醛的合成改进  

Synthetic Improvement of Methyl n-Nonyl Acetaldehyde

作　　者：周敏[1] 何磊[1] 冯良东[1] 郭燏[2] 

机构地区：[1]淮阴工学院化学工程学院,江苏淮安223003 [2]南京工业大学化学工程学院,江苏南京210009

出　　处：《山东化工》2016年第6期9-11,共3页Shandong Chemical Industry

基　　金：江苏省自然科学青年基金(BK20130420);江苏省盐化工新材料工程实验室开放基金(SF201305);淮阴工学院科研基金(HGB1203)

摘　　要：以甲基壬基酮、氯乙酸甲酯和甲醇钠为起始原料,经Darzens缩合、水解和脱羧反应合成甲基壬乙醛。在Darzens缩合时采用环己烷为溶剂,反应收率显著提升,达到87.9%。脱羧时通过使用对甲苯磺酸催化剂降低了反应温度,从而减少副产物的生成。通过以上改进,总收率可达77.3%。Methyl n- nonyl acetaldehyde was synthesized from 2- undecanone,methyl chloroacetate and sodium methoxide by Darzens reaction,hydrolysis and decarboxylation. Cyclohexane as solvent,the condensation rate was greatly improved and reached 87. 9% on the Darzens reaction. Toluene- p- sulfonic acid was used as catalytic agent on the decarboxylation reaction,the temperature of decarboxylation reaction and the production of by- product were reduced. Through these improvements,the total rate of methyl n- nonyl acetaldehyde reached 77. 3%.

关 键 词：合成 Darzens反应 甲基壬乙醛 

分 类 号：O624.5[理学—有机化学]