共混与同轴静电纺载药纳米纤维的制备、表征及比较  

Preparation,performance and comparison of co-electrospun and coaxial-electrospun drug-loaded PVA-SbQ/Zein composite nanofibers

作　　者：崔静[1] 邱玉宇[1] 卢杭诣 聂清欣 魏取福[1] 

机构地区：[1]江南大学生态纺织教育部重点实验室,江苏无锡214122

出　　处：《功能材料》2016年第4期55-59,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(51203064)

摘　　要：采用共混和同轴静电纺制备了负载盐酸四环素药物的聚乙烯醇-苯乙烯吡啶盐(PVA-SbQ)/玉米醇溶蛋白(Zein)复合纳米纤维,在紫外光照射下得到光交联载药PVA-SbQ/Zein复合纳米纤维。利用扫描电镜(SEM)对不同纤维的形貌和直径分布进行了分析;采用透射电镜(TEM)对不同静电纺丝法制备的纳米纤维结构进行了观察和比较;强力测试表明同轴静电纺丝制备的纳米纤维力学性能更强;傅里叶变换红外光谱(FT-IR)曲线表明载药PVA-SbQ/Zein复合纳米纤维保持了原有的化学功能基团;最后比较了两种方法制备的载药纳米纤维膜的药物释放行为。Drug tetracycline hydrochloride(TCH)-loaded PVA-SbQ/Zein composite nanofibers were fabricated by co-electrospinning and coaxial-electrospinning,respectively.Then the nanofibers were irradiated under UV light to get the cross-linked ones.The morphologies and diameter distributions of drug-loaded PVA-SbQ/Zein composite nanofibers were observed by SEM.TEM was used to compare the structure of the two kind of nanofibers.The strength test showed that the tensile strength of coaxial-electrospun nanofibers was better than the co-electrospun ones.The spectra of FT-IR indicated that composite nanofibers maintained their own original functional groups.Finally,the drug release behavior of drug-loaded nanofibers prepared with two methods was compared.

关 键 词：静电纺丝 聚乙烯醇-苯乙烯吡啶盐 玉米醇溶蛋白 载药纳米纤维 

分 类 号：TQ342.94[化学工程—化纤工业]