分级多孔结构聚乳酸支架的制备与性能研究  

Fabrication of PLLA scaffolds with hierarchical porous structure

作　　者：薄冬营 郭振招[1] 李红[1] 李启艳[2] 周长忍[1] 赵要武[3] 

机构地区：[1]暨南大学理工学院材料科学与工程系,广州510632 [2]云南省第一人民医院/昆明理工大学附属医院牙周种植科,昆明650032 [3]暨南大学医学院口腔系,广州510632

出　　处：《功能材料》2016年第4期210-213,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(31571008;81171459;81160134);广东省医学基金资助项目(A2013334)

摘　　要：以左旋聚乳酸为原料,1,4-二氧六环/水为溶剂,采用热致相分离法制备了具有分级多孔结构的组织工程支架。研究了溶剂配比、粗化时间对支架结构和性能的影响。溶剂比为87/13(1,4-二氧六环/水),PLLA浓度5%,粗化1h时,制备出大孔孔径达300μm,小孔嵌在大孔孔壁上且孔径在10μm以下的高连通分级多孔支架。粗化时间的延长使大孔孔径有所增大。细胞实验表明分级多孔支架有助于细胞长入支架内部,促进细胞的增殖。PLLA scaffolds with hierarchical porous structure were fabricated via a thermal induced phase separation in a 1,4-dioxane/water system.The effects of coarsening and the ratio of solvent/non-solvent on scaffold structure and properties were studied.Results indicated that the ratio of solvent/non-solvent affected the morphology of scaffolds.The scaffolds with interconnected and hierarchical porous structure presented macropores up to 300μm and micropores below 10μm embeded in the wall of macropores,when the ratio of 87/13(1,4-dioxane/water)was applied via coarsening for 1h.The macropore size increased with the extension of the coarsening time.Cell culture results showed that the hierarchical scaffolds were beneficial to the cell's ingrowth and cell proliferation.

关 键 词：左旋聚乳酸 热致相分离 分级 支架 

分 类 号：R318.08[医药卫生—生物医学工程]