石墨烯修饰玻碳电极测定氧氟沙星  

Application of Graphene Modified Glassy Carbon Electrode for the Detection of Ofloxacin

作　　者：卜晓阳[1] 钱丽[1] 何宝佳[1] 

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《唐山师范学院学报》2016年第2期35-37,共3页Journal of Tangshan Normal University

基　　金：安徽省大学生创新创业训练项目(AH201410368120);皖南医学院校中青年科研基金(WK201411)

摘　　要：通过超声混合得到稳定、均一的石墨烯-Nafion分散液,用滴涂法制备得到石墨烯-Nafion复合薄膜修饰玻碳电极。比较了氧氟沙星在未修饰玻碳电极和石墨烯-Nafion复合膜修饰玻碳电极上的电化学行为。结果表明石墨烯-Nafion复合膜修饰电极对氧氟沙星有电化学增强效应,并确定了最佳的实验条件。建立了一种快速、简便、灵敏度高的测定氧氟沙星的电化学方法。将该修饰电极用于氧氟沙星片剂中氧氟沙星含量的测定,回收率为99.1%~102.4%。The stable and uniform graphene-nafion dispersion was obtained by ultrasonic mixing. A glassy carbon electrode wasmodified with graphene-nafion composite membrane by casting. After having compared the electrochemical behavior of ofloxacin innon-modified glassy carbon electrode and graphene -nafion composite membrane modified electrode, it was found that the modifiedelectrode exhibits an excellent electro-catalytic activity toward the oxidation of ofloxacin, and the best experimental conditions havebeen determined by the result. The electrode with the fast, simple, sensive was developed for the detection of ofloxacin. The proposedmethod was applied successfully for determination of ofloxacin in drug samples. The recovery can reach 99.1%~102.4%.

关 键 词：石墨烯 Nafion复合膜 修饰电极 氧氟沙星 

分 类 号：R969.2[医药卫生—药理学]