α-actiniactinin-4在阿霉素肾病大鼠肾组织的表达差异及意义  

作　　者：杜宇[1] 王彩丽[1] 魏红[1] 李海涛[1] 

机构地区：[1]包头医学院第一附属医院,内蒙古014010

出　　处：《中华临床医师杂志（电子版）》2016年第4期3-3,共1页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的 分析α-actinin-4 在大鼠正常肾组织和阿霉素肾病大鼠不同病理类型肾组织的表达差异,以探讨该分子在蛋白尿发生中的可能作用及相互关系.方法 采用阿霉素制备大鼠模型,分析α-actinin-4 在不同病理类型大鼠肾组织中的表达.结果 α-actinin-4 在微小病变组表达增加（P〈0.01）,而在局灶节段性肾小球硬化组表达与对照组无明显差异.结论 α-actinin-4 在不同病理类型间存在差异,其表达的变化间接反映足细胞的损伤,提示了病变的活动情况.purpose Analysis of α-actinin - 4 normal kidney tissue of rats and adriamycin nephrosis expression in differentpathological type of renal tissue of rats, to explore the molecular in the possible role and relationship between proteinuria occurred. MethodsThe preparation of adriamycin rat model, analysis of α-actinin - 4 kidney tissues in rats in different pathological type of expression. Resultα-actinin - 4 expressed in tiny lesions group increased （P 〈 0.05）, while in focal segmental glomerular sclerosis express no obvious differencewith the control group.Conclusion α- actinin - 4 in the differences between the different pathological type, the change of its expressionindirectly reflect the damage of sertoli cell, prompt the lesions.

关 键 词：阿霉素肾病大鼠 鼠肾组织 表达差异 Α-ACTININ-4 局灶节段性肾小球硬化 病理类型 微小病变 大鼠模型 

分 类 号：R285.5[医药卫生—中药学]